Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Mar 3;227(11):1245–1254. doi: 10.1093/infdis/jiad056

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 2. — SARS-CoV-2 spread to and replication in the lung. Individual SARS-CoV-2 virions detected by in situ hybridization with ELF-97 substrate appear green and are approximately 0.25 μm. Nuclei stained blue with DAPI. Large numbers of virions are amassed in RBs of varying size. A, Virus production and spread in bronchiolar epithelium leave a visible trace of the hub and spoke mode of spread from branching terminal bronchioles into the lung parenchyma (encircled). B, Virus is concentrated in RBs in fused lysed ATI cells lining alveolar walls. C, Virus spread and fusion of spatially contiguous ATII cells generate focal clusters of virus-producing cells. D, Syncytial mat of virus RBs in lysed epithelium. Abbreviations: AT, alveolar type; RB, round body; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.