Additional Table 2.
List of exclusion studies
| Reason for exclusion | Title | Author | Source |
|---|---|---|---|
| Ozone associated with other therapies | A novel approach to treating COVID-19 using nutritional and oxidative therapies | David Brownstein; Richard Ng; Robert Rowen; Jennie-Dare Drummond; Taylor Eason; Hailey Brownstein; Jessica Brownstein | Science, Public Health Policy, and The Law, 2020, 2:4-22 |
| Ozone associated with other therapies | Ozone as adjuvant support in the treatment of COVID-19: A preliminary report of probiozovid trial | Araimo, Fabio; Imperiale, Carmela; Tordiglione, Paolo; Ceccarelli, Giancarlo; Borrazzo, Cristian; Alessandri, Francesco; Santinelli, Letizia; Innocenti, Giuseppe Pietro; Pinacchio, Claudia; Mauro, Vera; Recchia, Gregorio Egidio; Zancla, Serena; Calò, Andrea; Poscia, Roberto; Ruberto, Franco; d'Ettorre, Gabriella; Bilotta, Federico; Mastroianni, Claudio; Pugliese, Francesco | Journal of medical virology, 2020, 4(93):2210-20 |
| Ozone associated with other therapies | Ozone gas applied through nebulization as adjuvant treatment for lung respiratory diseases due to COVID-19 infections: a prospective randomized trial | Dengiz, E.; Özcan, Ç.; Güven, Y.İ.; Uçar, S.; Ener, B.K.; Sözen, S.; Yağcı, B.; Güzel, İ.A.; Yiğit, B.; Andaç, A.; Güneş, B.; Bor, E.; Karabudak, U.; Kaya, A. | Med Gas Res. 2022 Apr-Jun;12(2):55-59 |
| Ozone associated with other therapies | Effectiveness of ozone therapy in addition to conventional treatment on mortality in patients with COVID-19 | Çolak, S.; Genç, Y B.; Yavuz, M.; Özçelik, B.; Öner, M.; Özgültekin, A.; Senbayrak, S. | Int J Clin Pract; 75(8): e14321, 2021 Aug. |
| Ozone associated with other therapies | CORonavirus-19 mild to moderate pneumonia Management with blood Ozonization in patients with Respiratory failure (CORMOR) multicentric prospective randomized clinical trial | Sozio, E.; De Monte, A.; Sermann, G.; Bassi, F.; Sacchet, D.; Sbrana, F.; Ripoli, A.; Curcio, F.; Fabris, M.; Marengo, S.; Italiani, D.; Luciana, Boccalatte-Rosa, D.; Tascini, C. | Int Immunopharmacol. 2021 Sep;98:107874. |
| Ozone associated with other therapies | Compassionate Use of Rectal Ozone (O 3) in Severe COVID-19 Pneumonia: a Case-Control Study | Fernández-Cuadros, M.E.; Albaladejo-Florín, M.J.; Álava-Rabasa, S.; Gallego-Galiana, J.; Pérez-Cruz, G.F.; Usandizaga-Elio, I.; Pacios, E.; Torres-García, D.E.; Peña-Lora, D.; Casique-Bocanegra, L.; López-Muñoz, M.J.; Rodríguez-de-Cía, J.; Pérez-Moro, O. S. | SN Compr Clin Med. 2021 Mar 22;1-15. |
| Pre-covid study | Intravenous ozonized saline therapy as prophylaxis for healthcare workers (HCWs) in a dedicated COVID-19 hospital in India – A retrospective study | Sharma, A.; Shah, M.; Sane, H.; Gokulchandran, N.; Paranjape, A.; Khubchandani, P.; Captain, J.; Shirke, S.; Kulkarni, P. | Eur Rev Med Pharmacol Sci, 2021; 25 (9): 3632-3639 |
| Pre-covid study | Could the minor autohemotherapy be a complementary therapy for healthcare professionals to prevent COVID-19 infection? | Orscelik, A.; Karaaslan, B.; Agiragac, B.;Solmaz, I.; Parpucu, M. | Annals of Medical of Research, 28(10):1863-1869, 2021 |
| Post-covid study | Amelioration of symptoms and oxidative stress in hospitalized convalescent post SARS-COV-2 patients treated with rectal ozonetherapy and nutritional supplementation | Lizette Gil-del-Valle; Olga Elena López-Fernández; Joniel Arnoldo Sánchez- Márquez; Zullyt ZamoraRodríguez; Ana Librada Carballo- Reyes; Lidia Asela Fernández-García; Mario Manuel Delgado-Guerra; Faustina Fonseca-Betancourt; Ernesto Miyares-Díaz; Yasmina Piloto, Orraca.; Yusimit, B.A.; Maria Carla Hdez Glez-Abreu; Sarahi Mendoza-Castaño; Yamila Ramona de Armas-Aguila. | International Journal of Modern Pharmaceutical Research, 2020, 4(6):94-107 |
| Post-covid study | Fatigue in post-acute sequelae of SARS-CoV2 (PASC) treated with oxygen-ozone autohemotherapy - preliminary results on 100 patients | Tirelli, U.; Franzini, M.; Valdenassi, L.; Pisconti, S.; Taibi, R.; Torrisi, C.; Pandolfi, S.; Chirumbolo, S. | Eur Rev Med Pharmacol Sci, 2021 Sep;25(18):5871-5875 |
| Editorials | Homeopathic use of Ozonum for some post-Covid dyspnea and/or asthenia. Study based on a cases serie | Renoux, H. | La Revue d'Homéopathie, 2021, 12 (4), 222-227 |
| Editorials | Oxygen–ozone treatment and COVID-19: antioxidants targeting endothelia lead the scenery | Varesi, A.; Chirumbolo, S.; Ricevuti, G. | Intern Emerg Med, 2022, 17(2):593-596 |
| Editorials | COVID-19 profilaxis with ozonetherapy | Falzoni, W.; Senvaitis, M. I.; Iwasa, S. | Acupuncture and Electro-Therapeutics Research, 2021, 46(1):35-36 |
| Editorials | Persistent anosmia after COVID-19 Infection: Treatment options according to BDORT | Dotta Barros, F. C.; Iwasa, S. | Acupuncture and Electro-Therapeutics Research, 2021, 46(1):33-34 |
| Editorials | Ozone therapy may be an option for COVID-19 patients | Şahin, M.; Eryilmaz, F.; Keser Şahin, H.H. | Eur Rev Med Pharmacol Sci, 2021; 25 (6): 2470-2472 |
| Editorials | Oxygen-ozone autohemotherapy against COVID-19 needs to fit highly experienced, customized, and standardized protocols to succeed | Chirumbolo, S.; Franzini, M.; Simonetti, V.; Valdenassi, L.; Ricevuti, G.; Bertossi, D.; Pandolfi, S. | J Med Virol, 2021, 93(5):2580-2582 |
| Editorials | Estado vegetativo persistente por ozonoterapia contra Covid-19 | Zavala Jonguitud, L.F.; Solís, J.G.; Noyola García, M. | Salud Publica Mex, 2021, 63:155 |
| Editorials | A Plausible "Penny" Costing Effective Treatment for Corona Virus - Ozone Therapy | Robert Jay Rowen; Howard Robins | Infectious Diseases and Epidemiology, 2020, 6(2):1-5 |
| Editorials | Inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by gaseous ozone treatment. | Yano, H.; Nakano, R.; Suzuki, Y; Nakano, A.; Kasahara, K.; Hosoi, H. | The Journal of hospital infection, 2020, 4(106)837-8 |
| Editorials | Oxygen-ozone immunoceutical therapy in COVID-19 outbreak: facts and figures | Giovanni Ricevuti; Marianno Franzini; Luigi Valdenassi | Ozone Therapy, 2020, 1(5) |
| Editorials | Oxygen-ozone therapy as adjuvant in the current emergency in SARS-COV-2 infection: a clinical study. | Marini, S.; Maggiorotti, M.; Dardes, N.; Bonetti, M.; Martinelli, M.; Re, L.; Carinci, F.; Tavera, C. | Journal of biological regulators and homeostatic agents, 2020, 3(34):757-66 |
| Editorials | Ozone Therapy as a Possible Option in COVID-19 Management. | Gavazza, Alessandra; Marchegiani, Andrea; Rossi, Giacomo; Franzini, Marianno; Spaterna, Andrea; Mangiaterra, Sara; Cerquetella, Matteo | Frontiers in Public Health, 2020, 8:417 |
| Editorials | Ozonioterapia como adjuvante no tratamento da COVID-19 / Ozone as a complement therapy in the treatment of COVID-19 | Jorge Bomfim Fróes de Farias; Antonio Pedro Fróes de Farias; Anelize Gimenez de Souza | Revista Brasileira de Fisiologia do Exercicio, 2020, 19(2):5-8 |
| Editorials | Potential mechanisms by which the oxygen-ozone (O2-O3) therapy could contribute to the treatment against the coronavirus COVID-19. | Valdenassi, L.; Franzini, M.; Ricevuti, G.; Rinaldi, L.; Galoforo, A. C.; Tirelli, U. | European review for medical and pharmacological sciences, 2020, 8(24):4059-61 |
| Editorials | Recovery of Four COVID-19 Patients via Ozonated Autohemotherapy. | Wu, Junping; Tan, Cherie S.; Yu, Hongzhi; Wang, Youwei; Tian, Yutao; Shao, Wenwei; Zhang, Yifei; Zhang, Kuo; Shao, Hongxia; Ni, Guangjian; Shen, Jun; Galoforo, Antonio Carlo; Wu, Qi; Ming, Dong | Innovation (New York, N.Y.), 2020, 3(1)100060 |
| Editorials | The need for a correct oxygen-ozone autohemotherapy (O(3)-AHT) in patients with mild to moderate COVID -19 pneumo nia | Chirumbolo, Salvatore; Pandolfi, Sergio; Valdenassi, Luigi; Bertossi, Dario; Franzini, Marianno | Internal and Emergency Medicine, 2021, P.1-2 |
| Editorials | Utilização do gás ozônio e da ozonioterapia no combate à disseminação da COVID-19 submetidas pela Sociedade Brasileira de Ozonioterapia Médica (SOBOM) | Brasil. Ministério da Saúde. Secretaria de Ciencia, Tecnologia, Inovação e Insumos Estratégicos em Saúde. | Brasília; Brasil. Ministério da Saúde; abr. 2020. |
| Literature review | Dos terapias conocidas podrían ser efectivas como adyuvantes en el paciente crítico infectado por COVID-19 | Hernández, A.; Papadakos, P. J.; Torres, A.; González, D. A.; Vives, M.; Ferrando, C.; Baeza, J. | Rev. esp. anestesiol. reanim, 2020, 5(67):245-242 |
| Literature review | Implicações sobre o uso do ozônio (O3) no tratamento coadjuvante do COVID-19 | Jorge Bomfim Fróes de Farias; Antonio Pedro Fróes de Farias; Anelize Gimenez de Souza | Revista Brasileira de Fisiologia do Exercício, 2020, 4(106):5-8 |
| Literature review | Ozone (O3) and SARS-CoV-2: Physiological Bases and Their Therapeutic Possibilities According to COVID-19 Evolutionary Stage. | Fernández-Cuadros, Marcos Edgar; Albaladejo-Florín, María Jesús; Peña-Lora, Daiana; Álava-Rabasa, Sandra; Pérez-Moro, Olga Susana | SN comprehensive clinical medicine, 2020, p.1-9 |
| Literature review | Ozone potential to fight against SAR-COV-2 pandemic: facts and research needs. | Blanco, Angeles; Ojembarrena, Francisco de Borja; Clavo, Bernardino; Negro, Carlos | Environmental science and pollution research international, 2021, p.1-15 |
| Literature review | Ozone therapy for the treatment of COVID-19 pneumonia: A scoping review. | Izadi, Morteza; Cegolon, Luca; Javanbakht, Mohammad; Sarafzadeh, Ali; Abolghasemi, Hassan; Alishiri, Gholamhossein; Zhao, Shi; Einollahi, Behzad; Kashaki, Mandana; Jonaidi-Jafari, Nematollah; Asadi, Mosa; Jafari, Ramezan; Fathi, Saeid; Nikoueinejad, Hassan; Ebrahimi, Mehrdad; Imanizadeh, Sina; Ghazale, Amir Hosein | Int Immunopharmacol, 2021, 92:107307 |
| Literature review | Ozone therapy in COVID-19: A narrative review. | Francesco Cattel; Susanna Giordano; Cecilia Bertiond; Tommaso Lupia; Silvia Corcione; Matilde Scaldaferri; Lorenzo Angelone; Francesco Giuseppe De Rosa | Virus Research, 2021, 291:198207 |
| Literature review | Ozone: A Potential Oxidant for COVID-19 Virus (SARS-CoV-2) | Chedly Tizaoui | Ozone: Science & Engineering, 2020, 42(5):378-85 |
| Literature review | Ozonetherapy: a multirole weapon, topical pathway against SARS-COV-2 | Giovanni Ranaldi; Emanuele Rocco; VillaniLaura Franza; Giulia Motola | Frenxiv, 2020, p.1-11 |
| Literature review | Ozonoterapia enteral: una posible opción segura y económica para pacientes con COVID-19 | Vivian Borroto Rodríguez; Antonio Jiménez Tapia; María Esther Dragustinovis Ruiz | Revista Cubana de Medicina Física y Rehabilitación, 2020, 12(3):1-16 |
| Literature review | Ozonoterapia para el tratamiento de pacientes adultos con COVID-19 | Peru. EsSalud Instituto de Evaluación de Tecnologías en Salud e Investigación | Peru. EsSalud. Instituto de Evaluación de Tecnologías en Salud e Investigación. s.l; IETSI; 1 jun. 2020. |
| Literature review | Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19. | Martínez-Sánchez, Gregorio; Schwartz, Adriana; Donna, Vincenzo Di | Antioxidants (Basel, Switzerland), 2020, 9(5)1-12 |
| Literature review | Potential use of ozone in SARS-CoV-2 / COVID-19 | Therapy, International Scientific Committee of Ozone | International Scientific Committee of Ozone Therapy. Madrid; s.n; mar. 2020. p.2-15 |
| Literature review | Rationale for ozone-therapy as an adjuvant therapy in COVID-19: a narrative review. | Ranaldi, Giovanni Tommaso; Villani, Emanuele Rocco; Franza, Laura | Medical Gas Research, 2020, 3(10):134-8 |
| Literature review | Recent case studies on the use of ozone to combat coronavirus: Problems and perspectives. | Manjunath, Soumya Nagashri; Sakar, M.; Katapadi, Manmohan; Geetha Balakrishna, R. | Environmental Technology & Innovation, 2021, 21:101313 |
| Literature review | Safety, pitfalls, and misunderstandings about the use of ozone therapy as a regenerative medicine tool. A narrative review. | Re, L.; Noci, J. B.; Gadelha Serra, M. E.; Mollica, P.; Bonetti, M.; Travagli, V. | Journal of biological regulators and homeostatic agents, 2020, 4(34):1-3 |
| Literature review | SARS-COV-2 and Ozonetherapyin microcirculation: Devils and Angels~lll | Giovanni T. Ranaldi; Emanuele Rocco Villani; Laura Franza; Giulia Motola. | Frenxiv, 2020 |
| Literature review | Therapeutic Effects of Ozone Therapy that Justifies Its Use for the Treatment of COVID-19 | Silvia Menendez-Cepero; José Antonio Marques-Magallanes-Regojo; Alberto Hernandez-Martinez; Francisco Javier Hidalgo Tallón; JoséBaeza-Noci | Journal of Neurology and Neurocritical Care, 2020, 3(1):1-6 |
| Literature review | Two known therapies could be useful as adjuvant therapy in critical patients infected by COVID-19. | Hernández, A.; Papadakos, P. J.; Torres, A.; González, D. A.; Vives, M.; Ferrando, C.; Baeza, J. | Revista espanola de anestesiologia y reanimacion, 2020, 5(67):245-52 |
| Literature review | Observancia de reacciones adversas y análisis de cumplimiento de bioseguridad en la aplicación rectal de ozonoterapia en pacientes cubanos con infección aguda o convalecientes de COVID-19. | Lizette Gil del Valle, Mario M. Delgado Guerra, Ana L. Carballo- Reyes, Joniel A. Sánchez Márquez, Olga E. López Fernández, Faustina Fonseca Betancourt, Zullyt Zamora-Rodríguez, Lidia A. Fernández García, Rodolfo Suárez Iznaga, Raiza Martinez Casanueva, Lisandra Castro de la Fe, Niorkidis Gonzalez Carvajal, Silvia V. Castellanos Veitia, Yamila R. de Armas-Aguila | J Pharm Pharmacogn Res, 2021, 9(4): 465-473 |
| Literature review | Promising gas therapies for severe COVID-19 | Wang, T.; Xiang, Q.; Bian, Jinjun. | Journal of Intensive Medicine; 2021. |
| Literature review | The possibilities of using the effects of ozone therapy in neurology | Masan, J.; Sramka, M.; Rabarova, D. | Neuro Endocrinol Lett. 2021 Mar;42(1):13-21. |
| Literature review | COVID-19 and ozone | Yilmaz, N.; Eren, E.; Oz, C. | Cyprus Journal of Medical Sciences, 2020, 5(4):365-372 |
| Literature review | Ozonum—The Global Impact | Gajdos, P. S. | Homoeopathic Links, 2020, 33(4):283-296 |
| Literature review | Potential therapeutic effect of oxygen-ozone in controlling of COVID-19 disease. | Yousefi, B.; Banihashemian, S.Z.; Feyzabadi, Z.K.; Hasanpour, S.; Kokhaei, P.; Abdolshahi, A.; Emadi, A.; Eslami, M. | Med Gas Res, 2022, 12(2):33-40 |
| Literature review | Insights on the mechanisms of action of ozone in the medical therapy against COVID-19 | Chirumbolo, S.; Valdenassi, L.; Simonetti, V; Bertossi, D.; Ricevuti, G.; Franzini, M.; Pandolfi, S. | Int Immunopharmacol, 2021, 96:107777 |
| Literature review | Using Ozone Therapy as an Option for Treatment of COVID-19 Patients: A Scoping Review | Radvar, S.; Karkon-Shayan, S.; Motamed-Sanaye, A.; Majidi, M.; Hajebrahimi, S.; Taleschian-Tabrizi, N.; Pashazadeh, F.; Sahebkar, A. | Adv Exp Med Biol, 2021, 1327:151-160 |
| Literature review | Drug Repurposing in the COVID-19 Era: Insights from Case Studies Showing Pharmaceutical Peculiarities | Gatti, M.; De Ponti, F. | Pharmaceutics, 2021, 25;13(3):302 |
| Literature review | Alternative therapies for Covid-19 | Sundararajan, G.; Isaac, PJ.; Andal, V.; Lakshmipathy, R. | Mater Today Proc, 2021, 5;55:327-9 |
| Literature review | Ozonoterapia: una propuesta terapéutica para la prevención y el tratamiento de la infección por coronavirus SARS-COV-2 "COVID 19 | Longas Vélez, B.; Muñoz Mejía, C. A.; Ramírez Amaya, C. A.; Gaviria Morales, C.; Sarasti Vanegas, D. A.; Ramírez Zuluaga, E.; Trujillo Escobar, G.; Ríos Arenas, J. A.; Gaitán Sánchez, J. F.; Londoño Murillo, M. C.; Martínez Cadavid, M. M.; Soto Velásquez, M. L.; Álvarez Upegui, N.; Pérez Garcíí, C. L.; Mejía Alfaro, J. H. | Medellin – Colombia 2020 |
| Clinical trials registers | Ozone Plasma on Lung Function and Inflammatory Parameters in Pulmonary Sequelae Associated With Coronavirus 19 Infection | Fernando Grover Paez, Centro Universitario de Ciencias de la Salud, Mexico | https://clinicaltrials.gov/show/NCT05089305 |
| Clinical trials registers | Rectal ozone therapy in high-risk symptomatic SARS-CoV-2 positive patients | National Center for Scientific Research (CNIC) | https://rpcec.sld.cu/en/trials/RPCEC00000383-En |
| Clinical trials registers | Evaluation of Post-covid 19 Patients Who Receive Ozonetheraphy With Thorax CT | Gaziosmanpasa Research and Education Hospital | https://clinicaltrials.gov/show/NCT04789395 |
| Clinical trials registers | Study on ozonated blood in COVID-19 severe pneumonia | Políclinica Nuestra Señora del Rosario | https://www.clinicaltrialsregister.eu/ctr-search/search?query=eudract_number:2020-005020-11 |
| Full paper in Russian | Ozone Therapy In Patients With The New Coronavirus Infection Covid-19 | Hammad, E.V.; Nikitin, I.G.; Fedorova, K.V | Bulletin of Rehabilitation Medicine, 2020, 5 (99): 94-100 |
| Full paper in Russian | Ozone therapy as a component of a comprehensive rehabilitation program for patients after polysegmental pneumonia associated with SARS-CoV2 infection | Baranova, I. V; Gumeniuk, A. F.; Semenenko, A. I.; Iliuk, I. A.; Osypenko, I. P. | Zaporozhye Medical Journal, 2021, 23(6):752-758 |