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. 2023 May 29;13:8702. doi: 10.1038/s41598-023-35855-5

Table 4.

Estimated cumulative change for delayed recall and verbal fluency.

Outcomes Waves Estimate SE Standard error/estimate Fixed effect
Delayed recall Wave 2 0.00 0.00 999.00 0
Wave 4 1.28*** 0.22 5.79 Free
Wave 5 2.20*** 0.22 9.97 Free
Wave 6 3.18*** 0.23 14.15 Free
Wave 7 5.00 0.00 999.00 5
Verbal fluency Wave 2 0.00 0.00 999.00 0
Wave 4 2.13*** 0.25 8.66 Free
Wave 5 2.52*** 0.22 11.39 Free
Wave 6 3.43*** 0.23 14.95 Free
Wave 7 5.00 0.00 999.00 5

***p < 0.001.

As these are freely estimated time scores, waves 2 and 7 were fixed to 0 and 5 respectively. Delayed recall performance declined quite slowly between waves 2 and 4 (an estimated mean change of 1.28 in delayed recall in 4 years), followed by a more rapid decline between waves 4 and 6 (with an estimated mean change of 0.92 in 2 years between wave 4 and 5, and 0.98 between wave 5 and 6, thus a decline of 1.90 in 4 years), then this decline became even steeper between waves 6 and 7 (an estimated mean change of 1.82 in 2 years between waves 6 and 7).

Verbal fluency performance declined quite rapidly between waves 2 and 4 (an estimated mean change of 2.13 in verbal fluency in 4 years), followed by a slight decline between waves 4 and 5 (an estimated mean change of 0.39 in 2 years) and a more rapid decline between waves 5 and 6 (an estimated mean change of 0.91 in 2 years). Finally, this decline became even steeper between waves 6 and 7 (an estimated mean change of 1.57 in 2 years).