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. 2023 May 29;14:3082. doi: 10.1038/s41467-023-38415-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Genotypic diversity of 58 A(H5N1) viruses (some sequences generated directly from clinical material). A list of viruses used in this study and their GenBank or GISAID accession numbers are provided in Supplementary Tables 3 and 4, respectively. The colors denote common genotypes, with the orange color representing genes of Eurasian lineage and blue representing genes of NAm lineage (the different shades of blue represent phylogenetically distinct NAm genes). B Representative tangle plot showing the association of A(H5N1) virus HA genes (left side) with PB2 genes (right side) of Eurasian and NAm lineages. Nodes on the PB2 tree represent A(H5N1) viruses and representatives of other subtypes. Asterisks (*) indicate viruses that were used in subsequent experiments.