Table 3.
Comparison between ABodyBuilder, MOE, AlphaFold2 and NanoBodyBuilder2 at predicting the backbone atoms of nanobodies.
| Method | CDR1 | CDR2 | CDR3 | Fw |
|---|---|---|---|---|
| ABodyBuilder | 2.96 | 2.08 | 5.08 | 1.09 |
| MOE | 2.67 | 1.99 | 4.90 | 1.19 |
| AlphaFold2 | 2.08 | 1.35 | 3.44 | 0.82 |
| NanoBodyBuilder2 | 1.98 | 1.37 | 2.89 | 0.79 |
The mean RMSD to the crystal structure across the nanobody test set for each of the three CDRs and framework (Fw) is shown. RMSDs are given in Angstroms (Å). The best-performing method for each metric is highlighted in bold. The individual RMSDs for each method for each CDR are given in Supplementary Data 3.