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. 2023 May 29;13:8659. doi: 10.1038/s41598-023-35875-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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HHEX knockdown results in defective pancreatic endoderm generation. (A) A heatmap representing normalized Z-scores of pancreatic marker expressions in posterior foregut (PF) and pancreatic endoderm (PE) with or without HHEX knockdown. (B) Expressions of ONECUT1, ONECUT3 and EPCAM at Stage 4 with or without HHEX knockdown. (C) Temporal changes in the percentage of NKX6.1⁺PDX1⁺ cells under continued Stage 4 culture with (dotted line) or without HHEX knockdown (solid line). (D) Immunofluorescence images (left panels) and percentage (right panels) of CPEP⁺NKX6.1⁺ cells at Stage 6 with or without HHEX knockdown. Scale bars, 100 µm. The data from three independent experiments are presented as the mean ± SD (n = 3). *p < 0.05 and **p < 0.01 by two-tailed Student's t-test in (B) and by one-way ANOVA with Dunnett’s test for comparison with siControl in (D).