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. 2023 Apr 4;165(6):1483–1494. doi: 10.1007/s00701-023-05569-8

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Group data, comatose patients and healthy controls. Mean pupil size over time for healthy volunteers (left) and for comatose patients (right) with 95% CI. Red indicates values for the brimonidine-treated eye (right eye), and blue indicates values for the non-treated eye (left eye). Healthy volunteers showed a significant difference in pupil size from baseline to 30 min after brimonidine administration (p = 0.002), as well as a significant difference between the treated (right) and the non-treated (left) eye at the 30-min measurement (p < 0.001). Meanwhile, the comatose patients did not show a significant change in pupil size from baseline to 30 min after brimonidine administration (p = 0.06) nor between the treated (right) and the non-treated (left) eye at 30 min (p > 0.99)