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. 2023 Apr 4;165(6):1483–1494. doi: 10.1007/s00701-023-05569-8

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Individual data, comatose patients (A). Graphs with data from comatose patients (see legend to the right for patient specification). Pupil size over time (A1), for all 15 comatose patients. Five patients have missing values for the 120-min measurement. Difference in pupil size between treated eye (right eye) and non-treated eye (left eye) (A2), and absolute difference in pupil size from baseline (A3). Individual data, healthy controls (B). Graphs with data from healthy volunteers (see legend to the right for patient specification). Pupil size over time (B1), for all 15 healthy volunteers. Difference in pupil size between treated eye (right eye) and non-treated eye (left eye) (B2) and absolute difference in pupil size from baseline (B3)