Table 2.
Comatose patients, individual data
| Study id | Age | Sex | GCS | FOUR* | NPia | Admission cause | Time from study inclusion to death (days) | CT description | Inotropic level µg/kg/h (noradrenaline) | Sedation |
|---|---|---|---|---|---|---|---|---|---|---|
| A1 | 72 | Male | 7 | 9 (3, 1, 4, 1) | 3.7 | Anoxic brain injury | 3 | Cortical and subcortical loss of GM and WM differentiation | 8 | - |
| A2 | 53 | Male | 3 | 3 (0, 0, 2, 1) | 0 | OHCA | 0 | Loss of GM and WM differentiation and supra- and infratentorial cerebral edema | 6 | - |
| A3 | 65 | Female | 3 | 0 | 0 | ICH | 0 | ICH, MLS, IVH, hydrocephalus, and subfalcine herniation | 3 | - |
| A4 | 77 | Male | 3 | 7 (0, 0, 4, 3) | 2.4 | SAH | 0 | Hydrocephalus | - | - |
| A5 | 74 | Female | 3 | 5 (0, 0, 4, 1) | 0 | SAH | 16 | SAH, IVH, and bilateral thalamus infarction | - | - |
| A6 | 71 | Male | 5 | 7 (0, 2, 4, 1) | 4.7 | IHCA | 0 | Loss of GM and WM differentiation | - | - |
| A7 | 63 | Male | 5 | 7 (0, 2, 4, 1) | 4.6 | OHCA | 6 | Loss of GM and WM differentiation, cerebral edema, and bilateral infarcts | - | - |
| A8 | 73 | Female | 3 | 3 (0, 0, 2, 1) | 0 | ICH | 1 | Cerebral edema, ICH in basal ganglia, IVH, and hydrocephalus | - | Remifentanil 400 µg/h |
| A9 | 45 | Female | 3 | 0 | 0 | OHCA | 1 | Loss of GM and WM differentiation | 4 | - |
| A10 | 23 | Male | 4 | 4 (0, 1, 2, 1) | 0 | OHCA | 2 | Supratentorial hypoxic ischemic changes | - | Remifentanil 400 µg/h |
| A11 | 67 | Male | 3 | 7 (0, 0, 4, 3) | 3.8 | OHCA | 2 | Loss of GM and WM differentiation, and cerebral edema | - | Midazolam 10 mg × 1 30 min. before examination |
| A12 | 69 | Female | 3 | 2 (0, 0, 2, 0) | 0 | Cerebral infarct | 1 | Loss of GM and WM differentiation and cerebral edema | - | Remifentanil 1000 µg/h |
| A13 | 58 | Female | 3 | 2 (0, 0, 2, 0) | 3.6 | ICH | 0 | Pontine and mesencephalic bleeding, which compromises outflow from 4th ventricle | - | Remifentanil 750 µg/h |
| A14 | 47 | Female | 3 | 0 | 0 | SAH with OHCA | 0 | MLS, bioccipital hypodensities, and cerebral edema | - | - |
| A15 | 31 | Male | 3 | 3 (0, 0, 2, 1) | 4.2 | Anoxic brain injury | 7 | Preserved GM and WM differentiation | 16 | Remifentanil 250 µg/h |
Abbreviations: GCS Glasgow Coma Scale, FOUR Full Outline of UnResponsiveness score, CT computer tomography scan, OHCA out-of-hospital cardiac arrest, IHCA in-hospital cardiac arrest, ICH intracerebral hemorrhage, SAH subarachnoid hemorrhage, IVH intraventricular hemorrhage, MLS midline shift, GM gray matter, WM white matter
aNPi = proprietary index for pupillary light response; 0–3, abnormal; > 3–5, normal
*Numbers in parenthesis refer to FOUR scores for “eye response,” “motor response,” “brainstem reflexes,” and “respiration,” respectively