Table 2.
Changes in respiratory parameters during NHF-OT and COT
| Baseline | COT | NHF-OT | P value | |
|---|---|---|---|---|
| AHI (events/h) | 25.4 ± 8.6 | 19.4 ± 7.0 | 5.4 ± 4.6 | < 0.001 |
| CAI (events/h) | 0.3 ± 0.01 | 0.4 ± 0.01 | 0.4 ± 0.01 | 0.9 |
| HI (events/h) | 15.2 ± 4.1 | 9.4 ± 3.0 | 1.4 ± 0.6 | < 0.05 |
| Mean nocturnal SaO2, % | 86.2 ± 2.6 | 91.8 ± 2.4 | 93.9 ± 2.5 | < 0.001 |
| T90, % | 48.7 ± 20.1 | 16.8 ± 11.7 | 8.8 ± 8.0 | < 0.001 |
| ΔSaO2, % | 4.9 ± 0.8 | 3.7 ± 1.14 | 2.4 ± 1.0 | < 0.001 |
| Minimal nocturnal SaO2, % | 75.8 ± 7.9 | 81.5 ± 7.4 | 84.1 ± 7.7 | < 0.05 |
| PaO2, mmHg | 67.4 ± 6.2 | 67.8 ± 5.6 | 68.1 ± 4.8 | 0.9 |
| PaCO2, mmHg | 43.7 ± 4.6 | 44.2 ± 4.5 | 42.1 ± 5.8 | 0.3 |
| PH | 7.40 ± 0.02 | 7.39 ± 0.02 | 7.41 ± 0.02 | 0.8 |
Data are expressed as mean ± SD. AHI, apnea–hypopnea index; CAI, central-apnea index; HI, hypopnea index; T90, time below SaO2 90%; ΔSaO2, change in SaO2 during the respiratory event. ABG was obtained in the morning at room air at baseline and after treatment with COT or NHF-OT