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A variety of small molecules that serve as the ligands for MDM2 E3 ligase. (A‐D) Various small molecules (MDM2‐1–4) acting as MDM2 E3 ligase ligands and proposed tethering position in MDM2 ligand, based upon a co‐crystal structure of the MDM2 inhibitor nutlin‐3 and MDM2 protein (PDB ID: 4J3E).
