Table 3.
List of the Reactome pathways significantly connected to increased levels of proteins after A549 cell exposure to hypoxic conditions.
| Pathway name | Entities found | Entities total |
Entities´ pValue |
Entities´ FDR |
|---|---|---|---|---|
| Extracellular matrix organization |
6 (PLOD2, LOXL2, P4HA1, P4HA2, serpin E1, basigin) |
329 | 1.45E−4 | 8.4E−3 |
| Collagen formation | 4 (PLOD2, LOXL2, P4HA1, P4HA2) | 104 | 3.31E−5 | 5.77E−3 |
| SLC-mediated transmembrane transport | 4 (GLUT1, SLC2A3, SLC16A3, basigin) | 416 | 1.5E−2 | 1.03E−1 |
| Metabolism of carbohydrates | 4 (GLUT1, PFKL, PGK1, GBE1) | 456 | 2.14E−2 | 1.29E−1 |
| Collagen biosynthesis and modifying enzymes | 3 (PLOD2, P4HA1, P4HA2) | 76 | 2.46E−3 | 7.98E−2 |
| Pyruvate metabolism and Citric Acid cycle | 3 (SLC16A3, NNT, basigin) | 100 | 5.28E−3 | 7.98E−2 |
| Cellular hexose transport | 2 (GLUT1, SLC2A3) | 28 | 1.38E−4 | 8.4E−3 |
| Proton-coupled monocarboxylate transport | 2 (SLC16A3, basigin) | 12 | 8.43E−4 | 3.63E−2 |
| Glycolysis | 2 (PFKL, PGK1) | 110 | 6.85E−3 | 7.98E−2 |
| Basigin interactions | 2 (basigin, SLC16A3) | 26 | 3.84E−3 | 7.98E−2 |
| Vitamin C (ascorbate) metabolism | 2 (GLUT1, SLC2A3) | 26 | 3.84E−3 | 7.98E−2 |
| RAC3 GTPase cycle | 2 (TRIO, AMIGO2) | 100 | 4.82E−2 | 1.53E−1 |