Table 3.
Post-mortem multiple sclerosis (MS) cohort.
| ID, sex, age | Diagnosis | Cause of death | Post-mortem interval | MRI VRS burden | Number of retrieved tissue blocks | Pre- to post-mortem MRI interval |
|---|---|---|---|---|---|---|
| MS patients | ||||||
| MS1, M, 60 | PPMS | Brainstem stroke | 9 h | High | 14 | 16 months |
| MS2, F, 60 | Progressive MS | Sepsis | 7.5 h | Medium to high | 5 | N/A |
| MS3, F, 78 | Progressive MS | Pneumonia | 26 h | Medium | 7 | N/A |
| MS4, F, 57 | SPMS | Unknown | 89 h | Higha | 5 | 9 months |
| MS5, F, 78 | Progressive MS | Unknown | 12–15 h | Medium | 2 | N/A |
| MS6, F, 76 | RRMS | Unknown | <24 h | High | 9 | 8 months |
| Controls | ||||||
| C1, M, 46 | X-ALD | Sepsis | 48 h | Low | 4 | N/A |
| C2, F, 71 | Brain metastases (primary tumour unknown) | Unknown | <24 h | Medium | 3 | N/A |
| C3, M, 62 | Subarachnoid bleeding | Pneumonia | <24 h | Medium | 2 | N/A |
Brains from 6 multiple sclerosis (MS) patients and 3 control subjects were investigated for histopathological validation of (dilated) Virchow-Robin spaces (VRS).
Abbreviations: MRI, magnetic resonance imaging; N/A, not available; PPMS, primary progressive multiple sclerosis; SPMS, secondary progressive multiple sclerosis; RRMS, relapsing-remitting multiple sclerosis; X-ALD, X-linked adrenoleukodystrophy.
a
No postmortem MRI available. The VRS burden was evaluated macroscopically on brain slabs.