Table 4.
Summary of Multivariable Linear Regression Models Comparing Arterial Hemodynamics Among Women With History of Preeclampsia With and Without Severe Features, and Controls
| Variable | Nonsevere preeclampsia vs controls, aMD (95% CI) | Severe preeclampsia vs controls, aMD (95% CI) |
|---|---|---|
| Brachial blood pressure | ||
| SBP, mm Hg | +4.2 (−3.7, 12.05), P=0.293 | +9.1 (2.3, 15.9), P=0.010 |
| DBP, mm Hg | +6.2 (1.6–10.8), P=0.009 | +7.9 (2.7–13.2), P=0.004 |
| MAP, mm Hg | +8.9 (2.7–13.6), P=0.004 | +7.9 (1.7–14.2), P=0.014 |
| Brachial PP, mm Hg | +3.0 (−2.7, 8.6), P=0.295 | +3.8 (−10.2, 2.7), P=0.249 |
| Central blood pressure | ||
| Central SBP, mm Hg | +8.5 (−0.7, 17.7), P=0.070 | +11.2 (3.1–19.2), P=0.008 |
| Central DBP, mm Hg | +6.3 (1.6–11.0), P=0.010 | +8.0 (2.7–13.3), P=0.004 |
| Central PP, mm Hg | +5.0 (−1.4, 11.2), P=0.121 | +0.6 (−6.5, 7.6), P=0.882 |
| Aortic stiffness | ||
| cfPWV m/s | +0.19 (−0.26, 0.63), P=0.414 | +0.78 (0.27–1.29), P=0.003 |
| Steady arterial load | ||
| SVR, dyne×s/m5 | +290.4 (111.5–469.2), P=0.002 | +378.6 (178.0–579.4), P=0.0004 |
| Pulsatile arterial load | ||
| Zc, dyne×s/m5 | −1.67 (−29.53, 26.2), P=0.905 | −2.05 (−33.31, 29.22), P=0.896 |
| PAC, 10−6 cm4/dyne | −0.23 (−1.80, 2.26), P=0.820 | −1.20 (−3.47, 1.09), P=0.300 |
| TAC, mL/mm Hg | −0.09 (−0.35, 0.17), P=0.497 | −0.17 (−0.47, 0.13), P=0.256 |
| Pf, mm Hg | +0.1 (−5.3, 5.6), P=0.964 | −3.6 (−9.8, 2.5), P=0.240 |
| Arterial wave reflections | ||
| Pb, mm Hg | +2.7 (0.8–4.6), P=0.006 | +0.6 (−1.3, 2.7), P=0.593 |
| GRC | +0.06 (0.03–0.09), P=0.0003 | +0.04 (0.004–0.07), P=0.030 |
| AIx, % | +9.5 (4.9–14.2), P=0.001 | +7.5 (2.3–12.7), P=0.006 |
Results are presented as the aMD for each hemodynamic measure between women with preeclampsia and controls, after adjustment for confounders in the multivariable model. The reported P value refers to the comparison of each hemodynamic measure between the 2 groups. AIx indicates augmentation index; aMD, adjusted mean difference; cfPWV, carotid‐femoral pulse wave velocity; DBP, diastolic blood pressure; GRC, global reflection coefficient; MAP, mean arterial pressure; PAC, proximal aortic compliance; Pb, reflected pressure wave amplitude; Pf, forward pressure wave amplitude; PP, pulse pressure; SBP, systolic blood pressure; SVR, systemic vascular resistance; TAC, total arterial compliance; and Zc, aortic characteristic impedance.