Table 2.
LDL Cholesterol Profile (Before Initiation of Cholesterol‐Lowering Medication and Lp(a)‐Adjusted Values) Among Lp(a)/FH Groups
| FH/M− and lp(a) score=0 | FH/M− and lp(a) score≥1 | P value | FH/M+ and lp(a) score=0 | FH/M+ and lp(a) score≥1 | P value | |
|---|---|---|---|---|---|---|
| No. | 100 | 38 | 166 | 13 | ||
| Pretreatment LDL‐C, mg/dL; mean (SD) | 217.58 (62.72) | 213.80 (51.15) | 0.74 | 275.01 (560.23) | 260.49 (48.32) | 0.40 |
| Patients with pre‐treatment LDL‐C≥190 mg/dL; % | 67.00 | 68.42 | 0.87 | 95.18 | 92.31 | 0.65 |
| Lp(a)‐adjusted LDL‐C*; mean (SD) | 203.75 (62.68) | 183.52 (50.47) | 0.08 | 266.64 (59.22) | 236.42 (54.92) | 0.08 |
| Patients with Lp(a)‐adjusted LDL‐C* ≥190 mg/dL; % | 55.00 | 42.11 | 0.18 | 93.37 | 92.31 | 0.88 |
| Lp(a)‐adjusted LDL‐C†; mean (SD) | 209.60 (62.10) | 196.34 (49.92) | 0.24 | 270.18 (59.46) | 246.61 (51.18) | 0.17 |
| Patients with Lp(a)‐adjusted LDL‐C† ≥190 mg/dL; % | 59.00 | 50.00 | 0.34 | 94.58 | 92.31 | 0.73 |
FH indicates familial hypercholesterolemia; FH/M+, patients with genetic‐positive FH; FH/M−, patients with genetic‐negative FH; LDL‐C, low‐density lipoprotein cholesterol; and lp(a), lipoprotein(a).
*
Lp(a) corrected levels of LDL‐C calculated based on Dahlen formula. 13
†
Lp(a) corrected levels of LDL‐C calculated based on the study by Yeang et al. 14