Table 1.

Difference between phytosome and liposome.

Property	Phytosome	Liposome	Reference
Structure	The phytochemicals are conjugated to the hydrophilic choline head and it becomes a part of the phospholipid.	The active compounds are dissolved in intermate aqueous core or bilayer lipid membrane.	[2,9]
Nature of bond	Chemical bond (Hydrogen bonding)	No chemical bond	[2,48]
Drug: Phospholipid ratio	1:1 or 2:1 molecular complex	thousands of phospholipid molecules gathered around the drug	[2,48]
Encapsulation	H-bonds hold the bioactive molecules to the polar tip of the phospholipids.	The lipid bilayer membrane or the aqueous interior of the vesicles both contain active components.	[12]
Route of administation	Oral and topical	Topical and parenteral (No evidence exists for oral delivery.)	[48]
Bioavailability	High	Lower than phytosome	[48]
Stability	High	Lower than phytosome	[9,12]