REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
HDAC8	ABclonal	Cat# A8865, RRID: AB_2863620
H3K14ac	ABclonal	Cat# A7254
H3K9ac	ABclonal	Cat# A7255
H3K27ac	Cell Signaling Technology	Cat# 8173, RRID: AB_10949503
H4K16ac	ABclonal	Cat# A5280, RRID: AB_2766099
Actin	Cell Signaling Technology	Cat# 4970, RRID: AB_2223172
GFP	ABclonal	Cat# AE012, RRID: AB_2770402
Histone H3	Proteintech	Cat# 17168-1-AP, RRID: AB_2716755
Histone H4	ABclonal	Cat# A1131, RRID: AB_2758500
normal rabbit IgG	Millipore	Cat# 12–370, RRID: AB_145841
normal mouse IgG	Millipore	Cat# 12–371, RRID: AB_145840
rabbit anti-mouse IgG	Abcam	Cat# ab611709
anti-rabbit IgG	Millipore	Cat# AP132, RRID: AB_11214051
Chemicals
PCI34051	MedChemExpress	Cat# HY-15224
Butyrate	Sigma Aldrich	Cat# 303410
LPS	Sigma Aldrich	Cat# L4524
Esbilac formula	Abbott Laboratories	N/A
TRIzolTM Reagent	Invitrogen	Cat# 15596026
DMEM	Gibco	Cat# 11995065
Penicillin-Streptomycin	Gibco	Cat# 15140-022
Puromycin	Beyotime	Cat# ST551
Fetal Bovine Serum	Gibco	Cat# 10099-141C
Collagenase VIII	Sigma Aldrich	Cat# C2139
DNA Nase I	Sigma Aldrich	Cat# DN25
DTT	Sangon	Cat# B645939
0.5M EDTA	Sangon	Cat# B540625
HEPES	Sangon	Cat# C0215
RIPA buffer	Beyotime	Cat# P0013
Percoll	GE Healthcare Life Sciences	Cat# 17089101
Critical commercial assays
DNeasy PowerSoil kit	Qiagen	Cat# 12888
SimpleChIP® Plus Sonication	Cell Signaling Technology	Cat# 56383
Chromatin IP Kit
Hieff UNICON qPCR SYBR	Yeasen	Cat# 11198ES08
Green Master Mix
EvoM-MLV RT Premix	AG	Cat# AG11706
Deposited data
RNA-seq data (Figure 3D)	This paper	GSE212694
RNA-seq data (Figure 4)	This paper	GSE213187
CUT&Tag data	This paper	GSE213190
Experimental models: Cell lines
FHs74Int	ATCC	Cat# CCL-241, RRID: CVCL_2899
IEC6	ATCC	Cat# CRL-1592, RRID: CVCL_0343
Experimental models
Mouse: C57BL/6	Jiesijie Laboratory	Cat# 0653
Software and algorithms
GraphPad Prism 8	GraphPad	RRID:SCR_002798; http://www.graphpad.com/
Image Lab	Bio-Rad	RRID:SCR_014210; http://www.bio-rad.com/en-us/sku/1709690-image-lab-software
Genescloud	Personalbio	https://www.genescloud.cn
RRHO package ImageJ	R software ImageJ	Version 1.30.0 RRID:SCR_003070; https://imagej.nih.gov/ij/
SPSS 19.0	IBM	RRID:SCR_019096; https://www.ibm.com/products/spss-statistics