Fig. 3.

Protein fold-change line graphs for nonrespiratory oxygen-dependent pathways during aerobic and anaerobic growth. The fold-change values were plotted against the time relative to glucose depletion (t = 0) in hours for proteins involved in heme (A) and sterol (B) synthesis. The different colors of the line graphs represent “orange” the control yeast strain under anaerobic conditions (WT_AN) and “light blue” the control strain under aerobic conditions (WT_O2). The line graphs represent the average of the three biological replicates, where the error bars indicate the standard deviation. The gray dashed line represents the glucose concentration over time (mM, secondary y-axis). The number of quantified peptides per biological replicate are shown in brackets. Asterisks (∗) and circumflexes (ˆ) indicate the significance (p values) between the aerobic and anaerobic experiments as follows: p < 0.001 (∗∗∗), p < 0.01 (∗∗), p < 0.05 (∗), and p < 0.1 (ˆ).