Table 1.
In C. elegans | ||
---|---|---|
Function | Gene | References |
Metabolism |
ldh-2 (Lactate dehydrogenase), clk-1 (Coenzyme Q biosynthesis), glna-1 (Glutaminase), clec-4 (C-type lectin domain family member 4) |
(Nargund et al., 2012; Pellegrino et al., 2014; Nargund et al., 2015) |
Transcription factor | skn-1 (bZIP transcription factor, Nrf2 ortholog) | (Nargund et al., 2012; Nargund et al., 2015) |
Innate immunity |
lys-2 (lysozyme), abf-2, cnc-4 (antimicrobial peptide), clec-4 (C-type lectin domain family member 4) |
(Nargund et al., 2012; Pellegrino et al., 2014; Sapkota et al., 2021) |
Mitochondrial protein import |
tomm-20 (translocase of the outer membrane subunit), timm-17/23 (translocase of the inner membrane subunit 17/23) |
(Rainbolt et al., 2013; Nargund et al., 2012; Nargund et al., 2015) |
Mitochondrial protein homeostasis |
ppgn-1 (Mitochondrial paraplegin AAA protease), hsp-6 (Mitochondrial hsp70), dnj-10 (Mitochondrial DNA J), ymel-1 (Mitochondrial AAA protease) clpp-1 (Caseinolytic protease proteolytic subunit) |
(Haynes et al., 2007; Nargund et al., 2012; Nargund et al., 2015) |
Mitochondrial dynamics |
drp-1 (Dynamin-related protein), mff-2 (Mitochondrial fission factor-2) |
(Nargund et al., 2012; Nargund et al., 2015) |
In vertebrates | ||
Function | Gene | References |
Innate immunity | HD-5 (Antimicrobial peptide) | (Fiorese et al., 2016) |
Mitochondrial protein homeostasis | mtHSP70 (Mitochondrial chaperone), LON (Mitochondrial protease) CLPP (Caseinolytic protease proteolytic subunit) |
(Fiorese et al., 2016) |
Mitochondrial metabolism | ASNS (Asparagine synthetase) | (Fusakio et al., 2016) |
Mitokine | FGF21 (Fibroblast growth factor) | (Fusakio et al., 2016) |
Mitochondrial protein import | timm-23 (translocase of the inner membrane subunit 23) | (Rainbolt et al., 2013) |
MFN1 (Mitofusin 1) MFN2 (Mitofusin 2) OPA1 (Optic atrophy 1) |
(Wang et al., 2018) | |
Mitochondrial dynamics |
DRP1 (Dynamin-related protein) | (Kumar et al., 2022a) |