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. 2023 May 16;13:1135203. doi: 10.3389/fcimb.2023.1135203

Table 1.

UPRmt-induced genes in C. elegans and vertebrates.

In C. elegans
Function Gene References
Metabolism ldh-2 (Lactate dehydrogenase),
clk-1 (Coenzyme Q biosynthesis),
glna-1 (Glutaminase),
clec-4 (C-type lectin domain family member 4)
(Nargund et al., 2012; Pellegrino et al., 2014; Nargund et al., 2015)
Transcription factor skn-1 (bZIP transcription factor, Nrf2 ortholog) (Nargund et al., 2012; Nargund et al., 2015)
Innate immunity lys-2 (lysozyme),
abf-2, cnc-4 (antimicrobial peptide),
clec-4 (C-type lectin domain family member 4)
(Nargund et al., 2012; Pellegrino et al., 2014; Sapkota et al., 2021)
Mitochondrial protein import tomm-20 (translocase of the outer membrane subunit),
timm-17/23 (translocase of the inner membrane subunit 17/23)
(Rainbolt et al., 2013; Nargund et al., 2012; Nargund et al., 2015)
Mitochondrial protein homeostasis ppgn-1 (Mitochondrial paraplegin AAA protease),
hsp-6 (Mitochondrial hsp70),
dnj-10 (Mitochondrial DNA J),
ymel-1 (Mitochondrial AAA protease)
clpp-1 (Caseinolytic protease proteolytic subunit)
(Haynes et al., 2007; Nargund et al., 2012; Nargund et al., 2015)
Mitochondrial dynamics drp-1 (Dynamin-related protein),
mff-2 (Mitochondrial fission factor-2)
(Nargund et al., 2012; Nargund et al., 2015)
In vertebrates
Function Gene References
Innate immunity HD-5 (Antimicrobial peptide) (Fiorese et al., 2016)
Mitochondrial protein homeostasis mtHSP70 (Mitochondrial chaperone),
LON (Mitochondrial protease)
CLPP (Caseinolytic protease proteolytic subunit)
(Fiorese et al., 2016)
Mitochondrial metabolism ASNS (Asparagine synthetase) (Fusakio et al., 2016)
Mitokine FGF21 (Fibroblast growth factor) (Fusakio et al., 2016)
Mitochondrial protein import timm-23 (translocase of the inner membrane subunit 23) (Rainbolt et al., 2013)
MFN1 (Mitofusin 1)
MFN2 (Mitofusin 2)
OPA1 (Optic atrophy 1)
(Wang et al., 2018)
Mitochondrial
dynamics
DRP1 (Dynamin-related protein) (Kumar et al., 2022a)