Table 2.

Alteration in mitochondrial dynamics in response to various bacteria.

Bacteria	Affected protein(s)	Effector bacterial protein(s) involved	Consequent mitochondrial morphology	Effect on host and/or pathogen	References
Acinetobacter baumannii	DRP1	OmpA	Induces mitochondrial fragmentation	Induces host cell death	(Tiku et al., 2021)
Aeromonas hydrophila	DRP1	?	Induces mitochondrial fragmentation	Induces pathogen clearance	(Kumar et al., 2022a)
Chlamydia trachomatis	DRP1	?	Induces mitochondrial elongation	Improved pathogen survival	(Chowdhury et al., 2017; Kurihara et al., 2019)
Helicobacter pylori	DRP1	VacA	Induces mitochondrial fission	Induces host cell apoptosis	(Jain et al., 2011)
Legionella pneumophila	DRP1	MitF	Induces mitochondrial fission	Improved pathogen survival	(Escoll et al., 2017)
Listeria monocytogenes	MICOS10	LLO	Induces mitochondrial fission	Improved pathogen survival	(Stavru et al., 2011; Carvalho et al., 2020)
Mycobacterium tuberculosis	MFN2	ESAT6, LrpG	Induces mitochondrial hyperfusion	Induces inflammasome activation and IL-1β secretion	(Aguilar-López et al., 2019; Xu et al., 2020)
Shigella flexneri	DRP1	?	Induces mitochondrial fission	Induces non-apoptotic host cell death	(Lum and Morona, 2014)
Vibrio cholerae	Miro1 and Miro2	VopE	Prevents Mfn1-induced mitochondrial fusion	Inhibits host inflammatory responses	(Suzuki et al., 2014)

?, Not yet identified.