TABLE 4.
The ART history of the four affected individuals.
| Case | Cycle | No. of oocytes | No. of matured oocytes a | Pronucleus/pronuclei | Development outcomes of the embryos converted from 2 PN | Pregnancy outcomes | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | ≥3 | No. of embryos arrested at 2-5-cell stage | No. of embryos developing to ≥6 cells | |||||
| 1 | IVF | 10 | 8 | 1 | 0 | 0 | 7 | 0 | 0 | — |
| ICSI+AOA | 18 | 13 | 7 | 1 | 4 | 1 | 2 | 2 (6C2, 4BC) | Abortion b | |
| ICSI+AOA | 14 | 10 | 10 | 0 | 0 | 0 | 0 | 0 | — | |
| ICSI-donor sperm | 8 | 7 | 0 | 0 | 7 | 0 | 1 | 6 (7C3, 8C3, >10C3, >10C3, 4BC, 4BB) | Pregnancy | |
| 2 | IVF | 8 | 4 | 1 | 0 | 2 | 1 | 1 | 0 | — |
| ICSI+AOA | 7 | 4 | 1 | 1 | 2 | 0 | 1 | 1 (6C2) | NP | |
| 3 | IVF | 11 | 10 | 0 | 0 | 0 | 10 | 0 | 0 | — |
| ICSI+AOA | 10 | NA | NA | NA | NA | NA | NA | 0 | — | |
| ICSI+AOA | 7 | 6 | 4 | 0 | 2 | 0 | 0 | 2 (7C2, 7C3) | Live birth c | |
| 4 | IVF | 18 | NA | NA | NA | 6 | NA | NA | 0 | — |
| ICSI | 18 | 13 | NA | NA | 6 | NA | NA | 0 | — | |
| ICSI | 14 | NA | NA | NA | NA | NA | NA | 0 | — | |
| ICSI+AOA | 16 | 15 | 2 | 4 | 7 | 2 | 6 | 0 | — | |
NA, not applicable; NP, not pregnant.
a
The degenerated oocytes were not included here.
b
Chromosomal anomalies.
c
Boy-girl twins.
Good quality embryos: Grade 1–2, ≥7 cells.