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Schematic representation of pleiotropicinfluences of SARS-CoV-2 infection, physical activity and age on PGE2 levels and the ensuing altered immuneresponse (Ricke-Hoch et al., 2021). Reproduced with permission from Ricke-Hoch et al., 2021. (A) SARS-CoV-2 infection, physical inactivity, sex and older age are modulators of PGE2 synthesis and degradation, which are also risk factors for more severe COVID-19 disease courses. (B)PGE2 lowers the immune response and the formation of immunity.
