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. 2023 May 12;14:1173855. doi: 10.3389/fphar.2023.1173855

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Copyright © 2023 Liu, Shi, Tian, Zhai, Liu, Xiong and Chu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic figure of present study (Feng et al., 2021). Reproduced with permission from Feng et al., 2021. A cellular model of HMGB1 overexpression and knockdown was established in H9c2 cells, and HMGB1 was found to enhance the protective effect of taxifolin on these cells, probably through the PI3K/AKT/mTOR/ERK signaling pathway.