Pathogen detection among adults with community-acquired pneumonia (CAP) requiring hospitalisation in Thuringia, Germany in 2021. For all patients enrolled in the study, nasopharyngeal swabs and urine were collected and multiplex PCR for 10 respiratory viruses and urinary antigen tests for the C-wall polysaccharide (BinaxNOW Streptococcus pneumoniae) and serotype antigens (urinary antigen detection assay) were performed. Results from the per-protocol and standard-of-care testing are shown. a) Eligibility, enrolment and analysis of patients with CAP. b) Total number of enrolled adults with radiologically confirmed hospitalised CAP, and proportion of patients with detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and S. pneumoniae between 4 January 2021 and 31 December 2021, by month. c) Proportion of CAP due to SARS-CoV-2, S. pneumoniae or other respiratory viruses, by age group and study period. d) Proportion of pathogens detected, according to age group and study period. n indicates the total number of pathogen detections. CXR: chest radiography; HRV: human rhinovirus; PIV: parainfluenza virus 1–4; RSV: respiratory syncytial virus A and B; HMPV: human metapneumovirus; HCoV: human coronavirus (229E, OC43, NL63); AdV: adenovirus; HBoV: human bocavirus; CMV: cytomegalovirus.