Table 3.
Incidence rate [95% confidence interval (CI)] of study endpoints according to pacing indication and AVH programming
| Patients | Endpoint | Standard pacing | AV hysteresis | RRR | P-value |
|---|---|---|---|---|---|
| Whole cohort | Cardiac death | 18/1296 1.4% (0.8–2.2) % |
13/1296 1.0% (0.5–1.7) % |
27.8% | 0.366 |
| Whole cohort | HF hospitalizations |
40/1296
3.1% (2.2–4.2) % |
17/1296
1.3% (0.8–2.1) % |
57.5% | 0.002 |
| Whole cohort a | Persistent AF |
67/870
7.7% (6.0–9.7) % |
62/1169
5.3% (4.1–6.7) % |
31.1% | 0.028 |
| SND | Cardiac death | 8/548 1.5% (0.6–2.9) % |
5/629 0.8% (0.3–1.8) % |
45.5% | 0.276 |
| SND | HF hospitalizations |
21/548
3.8% (2.4–5.8) % |
11/629
1.7% (0.9–3.1) % |
54.4% | 0.028 |
| SND a | Persistent AF |
32/251
12.7% (8.9–17.5) % |
41/522
7.9% (5.7–10.5) % |
38.4% | 0.029 |
| AV block | Cardiac death | 8/530 1.5% (0.7–3.0) % |
6/444 1.4% (0.5–2.9) % |
10.5% | 0.836 |
| AV block | HF hospitalizations | 10/530 1.9% (0.9–3.4) % |
5/444 1.1% (0.4–2.6) % |
40.3% | 0.337 |
| AV block a | Persistent AF |
22/488
4.5% (2.8–6.7) % |
8/434
1.8% (0.8–3.6) % |
60.0% | 0.023 |
| Other | Cardiac death | 2/218 0.9% (0.1–3.3) % |
2/223 0.9% (0.1–3.2) % |
2.2% | 0.982 |
| Other | HF hospitalizations |
9/218
4.1% (1.9–7.7) % |
1/223
0.4% (0.0–2.5) % |
89.1% | 0.009 |
| Othera | Persistent AF | 13/131 9.9% (5.4–16.4) % |
13/213 6.1% (3.3–10.2) % |
32.3% | 0.193 |
AF, atrial fibrillation; AV, atrioventricular; HF, heart failure; RRR, risk rate ratio; SND, sinus node disease.
a
Patients without history of persistent/permanent AF at inclusion. Bold values indicate all the endpoints with P < 0.05.