Table 1.
Baseline Characteristics of Participants By Age Cohort
| Younger (n=30) |
Older (n=192) |
P-value | |
|---|---|---|---|
|
| |||
| Age | 29.99 (3.83) | 76.43 (4.72) | <.0001 |
| Race/Ethnicity | <.0001 | ||
| Caucasian/White | 18 (60.0) | 173 (89.1) | |
| African American/Black | 4 (13.3) | 18 (9.4) | |
| Asian | 3 (10.0) | 1 (1.0) | |
| Multiracial/other | 5 (16.7) | 0 (0.5) | |
| Sex | 0.4659 | ||
| Men | 11 (36.7) | 84 (43.8) | |
| Women | 19 (63.3) | 108 (56.3) | |
| Years of Education | 16.93 (2.05) | 15.68 (2.45) | 0.0085 |
| BMI | 25.52 (5.05) | 28.39 (5.63) | 0.0091 |
| Diabetes | 0.0058 | ||
| No | 30 (100) | 152 (79.2) | |
| Yes | 0 (0.0) | 40 (20.8) | |
| Hypertension | <.0001 | ||
| No | 26 (86.7) | 92 (47.9) | |
| Yes | 4 (13.3) | 100 (52.1) | |
| Self-Reported Moderate Aerobic Activity Level | <.0001 | ||
| No Activity Reported | 0 (0.0) | 33 (17.2) | |
| Low <= 60min/week | 0 (0.0) | 45 (23.4) | |
| 60m/week < Mid <= 135m/week | 30 (100) | 60 (31.3) | |
| High > 135min/week | 0 (0.0) | 54 (28.1) | |
| MRI measures | |||
| Fractional anisotropy in the white matter for the motor region | 0.25 (0.01) (n=29) | 0.23 (0.02) (n=188) | <.0001 |
| Volume of lesions within the motor ROI in CC | 0.01 (0.01) | 1.02 (2.37) (n=191) | 0.0208 |
| Intracranial lesion volume CC | 0.15 (0.10) | 6.25 (9.14) (n=191) | 0.0003 |
| Intracranial volume CC | 1556.8 (217.60) | 1632.9 (178.71) (n=191) | 0.0368 |
| Volume of the motor ROI in CC | 88.26 (12.95) | 84.71 (9.81) | 0.0794 |
| Cognitive measures | |||
| MOCA Adjusted Score | 27.00 (5.44) | 25.64 (2.20) | 0.0153 |
| DSST | 81.20 (10.60) (n=25) | 55.18 (12.20) | <.0001 |
| Physical Function Measures | |||
| eSPPB | 2.81 (0.25) | 2.00 (0.52) (n=190) | <.0001 |
| 400m walk (m/sec) | 1.57 (0.21) | 1.27 (0.43) | 0.0002 |
Values are mean (SD) for continuous measures and counts (% within cohort) for categorical measures. CC = cubic centimeters.