TABLE 3.
Correlation between CysC/Cr and variants using linear regression analysis.
| Variant | Univariate models | Multivariate model (R = 0.68) | ||
|---|---|---|---|---|
| p‐Value | R | p‐Value | c.c. (95%CI) | |
| Female gender | <0.001 | 0.44 | <0.001 | 0.20 (0.12–0.29) |
| Older age | <0.001 | 0.58 | <0.001 | 0.01 (0.005–0.011) |
| BMD in LS | 0.16 | 0.14 | ||
| BMD in FN | 0.08 | 0.17 | ||
| T‐score in LS | 0.12 | 0.14 | ||
| T‐score in FN | 0.11 | 0.16 | ||
| Presence of lifestyle‐related diseases | 0.17 | 0.11 | ||
| Presence of hyper fall‐ability | 0.10 | 0.12 | ||
| Presence of CKD ≥ Grade3a | <0.001 | 0.16 | 0.12 | −0.07 (−0.15–0.02) |
| Presence of cognitive impairment | <0.05 | 0.17 | 0.6 | −0.04 (−0.18–0.10) |
| Antiosteoporotic drug administration | <0.001 | 0.44 | 0.94 | −0.003 (−0.09–0.08) |
| Vitamin D supplementation | 0.75 | 0.03 | ||
| Glucocorticoid steroid administration | 0.63 | 0.04 | ||
| Presence of polypharmacy | <0.05 | 0.16 | 0.20 | 0.05 (−0.03–0.12) |
| Presence of prevalent MOF | <0.001 | 0.48 | <0.05 | 0.10 (0.02–0.19) |
Abbreviations: BMD, bone mineral density; c.c., correlation coefficients; CKD, chronic kidney disease; CysC/Cr, serum cystatin C‐to‐creatinine ratio; FN, femoral neck; LS, lumbar spine; MOF, major osteoporotic fracture.