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Figure 7. Graphical overview of the structural capillary changes observed in DIPG pre-treatment biopsy and post-mortem autopsy samples:

Figure 7

lower expression of tight junction proteins claudin-5 and ZO-1, basement membrane component laminin, pericyte marker PDGFR-β and efflux transporter P-gp in DIPG biopsy and autopsy samples; unchanged expression of efflux transporter BCRP-1 in DIPG biopsy and autopsy samples.