Table 4.
Univariate and multivariable analysis of the effect of HIV status on TB treatment outcomes
| TB treatment outcome | Univariate analysis | Multivariable analysis | ||
|---|---|---|---|---|
| Crude Odds Ratio (95% CI) | P-value | Adjusted Odds ratio (95% CI)a | P-value | |
| Treatment complete | ||||
| HIV positive Vs negative | 0.62 (0.58‒0.67) | < 0.001 | 0.56 (0.52‒0.61) | < 0.001 |
| HIV unknown Vs negative | 0.56 (0.44‒0.71) | < 0.001 | 0.57 (0.44‒0.73) | < 0.001 |
| Crude HR (95% CI) | Adjusted HR (95% CI)a | |||
| Died | ||||
| HIV positive Vs negative | 2.32 (2.13‒2.53) | < 0.001 | 2.40 (2.18‒2.63) | < 0.001 |
| HIV unknown Vs negative | 2.34 (1.75‒3.12) | < 0.001 | 1.93 (1.44‒2.56) | < 0.001 |
| Defaulted/Lost-to-follow-up | ||||
| HIV positive Vs negative | 1.01 (0.88‒1.14) | 0.97 | 1.16 (1.01‒1.32) | 0.04 |
| HIV unknown Vs negative | 1.58 (1.04‒2.39) | 0.03 | 1.55 (1.02‒2.35) | 0.04 |
| Transfer out | ||||
| HIV positive Vs negative | 1.06 (0.91‒1.24) | 0.48 | 1.09 (0.92‒1.29) | 0.30 |
| HIV unknown Vs negative | 1.08 (0.59‒1.96) | 0.80 | 1.01 (0.56‒1.84) | 0.97 |
| Treatment failure | ||||
| HIV positive Vs negative | 0.85 (0.64‒1.13) | 0.27 | 1.08 (0.80‒1.46) | 0.62 |
| HIV unknown Vs negative | 1.19 (0.44‒3.20) | 0.73 | 1.54 (0.57‒4.15) | 0.40 |
aAdjusted for a priori confounders: age, sex, patient type, TB type, facility type, method of DOT, BMI, TB treatment regimen, type of TB diagnosis, presence of other underlying medical conditions and year of diagnosis, Odds Ratios are from multilevel logit regression model, Hazard Ratios are from Cox proportional hazard regression models