Table 3.

Summary of the purported effects of polyphenols in models of toxicity related to amyloid peptides.

Polyphenols	Study Model	Treatment Duration	Study Outcomes	Refs.
Curcumin	Aged APPsw Tg2576 mice	5 months	Reduced Aβ levels and plaque burden	[27]
	Parts of Tg2576 mouse brain	3-6 days	Suppressed Aβ aggregation; mediated disaggregation of Aβ
	Neuronal hippocampal cultures	1 to 24 hours	Suppressed the generation of Aβ fibrils and fibril-destabilizing activities
Resveratrol	Neuronal hippocampal cultures	2 hours	Blocked Aβ-induced toxicity	[30, 245, 246]
	Cells transfected with human APP695	24 hours	Mediated Aβ degradation
	Neuronal hippocampal cultures	24 hours	Showed anti-amyloidogenic properties
Myricetin	Neuronal hippocampal cultures	1 to 24 hours	Showed fibril-destabilizing properties; blocked Aβ(1-40)-induced toxicity; suppressed the generation of Aβ fibrils	[25]
EGCG	Neuronal hippocampal cultures	24-48 hours	Suppressed soluble forms of Aβ and Aβ fibrilization; blocked Aβ(1-42)-induced toxicity	[219, 263, 264]
	Tg APPsw mouse models	2 months	Reduced Aβ levels and Aβ plaques
	C57/BL mouse models; human neuroblastoma cells	7-14 days	Elevated the levels of sAPP release; mediated non-amyloidogenic pathway
Ellagic acid and Punicalagin	Tg APPsw/Tg2576 mouse models	6-8 months	Ameliorated AD-like pathology and behavior along with a reduced level of Aβ(1-42) and Aβ deposition	[172]
Gallic acid and tannic acid	Neuronal hippocampal cultures	1 to 24 hours	Showed fibril-destabilizing properties; blocked Aβ-induced toxicity; suppressed the generation of Aβ fibrils	[265]