TABLE 2.

Potential Preventive Actions and Treatments of Persistent Noninflammatory Nodules

		If Ultrasound is Available
Superficial fatty layer	•Keep the needle or cannula in a plane parallel once in the right layer •Lift the cannula to check its position	•Record the width of the superficial fatty layer before injection •For (self) education, check location of filler after placement
Deep fatty layer/periosteum	To control backflow of filler with needle: •Inject slowly •After injection, wait and then retract the needle To avoid injecting all product in the facia with cannula: •Puncture deeper, i.e., through skin and SMAS, then insert cannula	•Check the width of the fascia/SMAS before injection •For (self) education, check location of filler after placement
Dissolving persistent nodule	Inject hyaluronidase with a needle not only in the superficial but also in the deeper layers.	Inject hyaluronidase ultrasound guided into the hypoechoic nodule