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. 2023 Apr 3;59(6):855–863. doi: 10.1097/SHK.0000000000002122

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Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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FIG. 2 — Identification and validation of hypoxia-related hub genes. A, A Venn diagram program was used to reflect the intersection between WGCNA candidate genes and upregulated DEGs in GSE100159 and GSE80496 data sets. B, The GO enrichment analysis of intersection genes. C, The KEGG enrichment analysis of intersected genes. D, The PPI network of intersected genes, including ITGAM, TLR2, TLR4, S100A12, TLR8, FGR, CYBB, HK3, HIF-1α, and FCGR1A. E, The PPI network of hub genes. F, The intersections of hub genes and hypoxia gene set. G and H, The HIF-1α mRNA expression level in the sepsis is significantly higher than that in the nonsepsis group (P < 0.001) (GSE80496, GSE100159).