TABLE 2.

ROC curves in assessing the statue of sepsis

Variables	Cutoff values	Sensitivity (%)	Specificity (%)	AUC (95% CI)	Youden index	P
Model 3	0.418	0.896	0.852	0.926 (0.885–0.968)	0.748	0.001
Model 2	0.569	0.867	0.815	0.894 (0.844–0.945)	0.682	0.051
Model 1	1.268	0.792	0.907	0.897 (0.851–0.942)	0.699	0.049
HIF-1αadj	1.220	0.595	0.907	0.829 (0.769–0.890)	0.503	0.686
WBC	10.045	0.870	0.699	0.796 (0.736–0.856)	0.570	0.174
BUN	6.035	0.796	0.832	0.847 (0.794–0.901)	0.629	0.889
HIF-1α	2.429	0.630	0.647	0.614 (0.530–0.699)	0.277	<0.001
qSOFA	0.500	0.994	0.537	0.843 (0.780–0.905)	0.531	Ref.

HIF-1α_adj = HIF-1α × Fio₂/Spo₂. Model 1, HIF-1α_adj + BUN; model 2, HIF-1α_adj + WBC; model 3, HIF-1α_adj + WBC + BUN; P values: DeLong test was used for the comparison of different AUCs.

AUC, area under the curve; Ref., reference.