Table 5.
HAE attack rates during follow-up, overall and by country
| Overall (N = 131) | US (n = 34) | Canada (n = 42) | Germany (n = 17) | Australia (n = 19) | UK (n = 12) | Italy (n = 7) | |
|---|---|---|---|---|---|---|---|
| Annual attack rate | |||||||
| Mean ± SD | 20.2 ± 16.9 | 21.8 ± 17.5 | 17.4 ± 17.0 | 25.6 ± 13.5 | 17.8 ± 14.8 | 23.4 ± 24.7 | 17.5 ± 9.7 |
| Median (range) | 14.1 (0, 84.1) | 15.9 (0, 72.0) | 11.9 (0.3, 79.3) | 24.0 (4.0, 52.2) | 14.0 (2.0, 52.2) | 11.8 (0.3, 84.1) | 13.8 (6.0, 33.2) |
| Received LTPa | 79 (60.3) | 22 (64.7) | 28 (66.7) | 6 (35.3) | 11 (57.9) | 11 (91.7) | 1 (14.3) |
| Annual attack rate | |||||||
| Mean ± SD | 20.8 ± 18.9 | 26.9 ± 19.1 | 14.6 ± 13.2 | 35.4 ± 13.8 | 12.9 ± 15.2 | 25.0 ± 28.3 | 9.7 ± |
| Median (range) | 13.9 (0, 84.1) | 20.7 (0, 72.0) | 11.6 (0.3, 52.2) | 30.0 (24.0, 52.2) | 5.6 (1.1, 52.2) | 12.0 (0.3, 84.1) | 9.7 (9.7, 9.7) |
| Did not receive LTPa | 52 (39.7) | 12 (35.3) | 14 (33.3) | 11 (64.7) | 8 (42.1) | 1 (8.3) | 6 (85.7) |
| Annual attack rate | |||||||
| Mean ± SD | 20.3 ± 16.8 | 14.1 ± 14.7 | 23.4 ± 24.4 | 20.2 ± 10.3 | 22.9 ± 14.3 | 43.0 ± | 18.7 ± 10.1 |
| Median (range) | 15.7 (0.3, 79.3) | 9.4 (0.9, 48.2) | 15.7 (0.3, 79.3) | 24.0 (4.0, 36.0) | 23.8 (2.0, 52.2) | 43.0 (43.0, 43.0) | 18.9 (6.0, 33.2) |
Only patients with information on frequency of HAE attacks are included
HAE hereditary angioedema, LTP long-term prophylaxis, SD standard deviation
aLTP was or was not received during the period(s) in which frequency of HAE attacks was reported