Table 6.

Multivariable Poisson regression analysis of HAE attack rate during follow-up

	HAE attack rate (N = 131)
	IRR (95% CI)	P-value
Treatment type
Any LTP (ref: no LTP)	0.90 (0.84–0.96)	0.002
Baseline covariates
Male sex (ref: female)	0.94 (0.88–1.00)	0.043
Age at HAE diagnosis (per 10 years)	1.03 (1.01–1.05)	0.001
HAE attacks before index date (ref: < median)	1.67 (1.57–1.77)	< 0.001
Country of residence (ref: US)
Canada	0.76 (0.70–0.81)	< 0.001
Germany	0.91 (0.83–1.01)	0.075
Australia	0.85 (0.78–0.92)	< 0.001
UK	0.86 (0.76–0.97)	0.014
Italy	0.48 (0.37–0.63)	< 0.001
Family history of HAE (ref: no family history)	1.27 (1.17–1.37)	< 0.001
Type 1 HAE (ref: type 2 HAE)	0.81 (0.75–0.88)	< 0.001
Any preexisting comorbidity (ref: no preexisting comorbidity)	1.13 (1.07–1.20)	< 0.001
Previous misdiagnosis (ref: no previous misdiagnosis)	0.83 (0.75–0.91)	< 0.001

CI confidence interval, HAE hereditary angioedema, IRR incidence rate ratio, LTP long-term prophylaxis