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. 2023 May 30;16:21. doi: 10.1186/s13072-023-00492-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 10 — Examples of qualitatively different predicted radial distributions of several TADs, and their responses to lamin depletion. Top panel: Radial distribution of the PcG L-TAD #435 (cytological region 60D in Ref. [35]) in the WT and Lamin mutant nucleus models. Middle panel: Radial distribution of the Null L-TAD #120 (cytological region 36C in Ref. [35]) in the WT and Lamin mutant model nuclei. Bottom panel: Radial distribution of the Active TAD #22 in the WT and Lamin mutant model nuclei. The distributions of L-TADs (LADs) are bi-modal: the NE-bound mode is characterized by a high and very narrow density peak right at the NE, and the diffusive mode exhibits a noticeable LAD density in the nuclear interior. The bi-modality is consistent with the mobile nature of LADs