Table 2.
Stability of molnupiravir and NHC in rat blood and brain dialysates.
| Nominal concentration (ng/mL) | Autosampler stability (%) | Bench-top stability (%) | Freeze—thaw stability (%) | Long-term stability (%) |
|---|---|---|---|---|
| Molnupiravir | ± | |||
| Blood | ||||
| 5 | 98.57 ± 4.35 | 105.56 ± 1.73 | 105.23 ± 0.92 | 107.23 ± 0.74 |
| 250 | 100.31 ± 0.99 | 108.26 ± 3.29 | 103.92 ± 5.39 | 95.69 ± 0.04 |
| Brain | ||||
| 5 | 99.25 ± 0.36 | 100.99 ± 0.99 | 99.82 ± 1.63 | 99.641 ± 1.56 |
| 250 | 100.85 ± 0.70 | 103.61 ± 1.44 | 104.38 ± 1.35 | 99.17 ± 0.69 |
| NHC | ||||
| Blood | ||||
| 25 | 97.14 ± 1.02 | 105.16 ± 11.27 | 104.53 ± 8.98 | 102.09 ± 5.18 |
| 1000 | 99.52 ± 0.06 | 101.52 ± 1.26 | 101.02 ± 0.33 | 100.45 ± 0.54 |
| Brain | ||||
| 25 | 103.59 ± 5.26 | 103.03 ± 3.99 | 97.35 ± 5.21 | 112.26 ± 5.03 |
| 1000 | 102.58 ± 1.05 | 101.02 ± 0.81 | 101.49 ± 0.54 | 101.69 ± 0.49 |
Data are expressed as the mean ± SD (n = 3).