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. Author manuscript; available in PMC: 2023 May 30.
Published in final edited form as: Lab Invest. 2021 Nov 20;102(2):185–193. doi: 10.1038/s41374-021-00700-8

Fig. 2. EZH2 overexpression in pediatric brain tumors.

Fig. 2

A, B. High levels of EZH2 mRNA expression in high-grade glioma (upper panel) and MB (lower panel) patient tumors (Pt tum) and PDOX models during serial in vivo subtransplantation from passage I (Xeno-I) up to passage VIII (Xeno-VIII). Normal brain tissues were included as references. The data from glioma were extracted from gene expression profiling using Affy 133 array, and MB from illumine array. C Representative immunohistochemical staining images showing increased expression of H3K27me3 in MB models. D Western hybridization showing elevated H3K27me3 expression in xenograft tumors of PDOX models. Normal human cerebellar tissues obtained from warm autopsy were included as references.