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. Author manuscript; available in PMC: 2023 May 30.
Published in final edited form as: Lab Invest. 2021 Nov 20;102(2):185–193. doi: 10.1038/s41374-021-00700-8

Fig. 4. Histological changes induced by tazemetostat.

Fig. 4

A Schematic illustration of the timing of mouse brain collection after in vivo treatment. B H&E staining showing the in vivo growth of PDOX tumors (*) from low (4×) to high (40×). Compared with the untreated control, the remnant tumor of IC-L1115ATRT remained highly invasive although the number of satellite foci (red arrowhead) was slightly reduced (upper panel). The local invasion of IC-1078MB was not significantly affected (lower panel). Cell proliferation (Ki-67) in the remnant tumor was similar to the untreated controls.