Table 1.

Clinical, histological, and molecular features of the PDOX models.

Model ID	Age/Gender	Diagnosis	Metastatic/ Recurrent	Molecular subtype			References
				Pt tumor	PDOX	Sequenced
IC-2305GBM	9 y Female	GBM (small cell variant)	No/No	GBM-G34a	GBM-G34a	TP53, H3F3A (G34R), ATRX mutation	36,37
ICb-1078MB	11 y 9 mo Male	MB (anaplastic)	No/No	Group 4a	Group 4a,b	MYC, N-MYC amplification; PDZRN4, SCNNIB, and KNTC1 mutation	35,36
ICb-1572MB	14 y 9 mo Male	MB (large cell)	Yes/No	Group 3a	Group 3a,b	GARID1A mutation	34,35
IC-L1115ATRT	3 m Male	ATRT (from autopsy)	Yes/Yes	SHHa	SHHa	INI1 deletion	36

^aWith gene expression profiling.

^bDNA methylation.