Table III.

Summary of the MPS III associated with other diseases and gene mutation

Diseases which are found to be associated with MPS IIIB	Gene	Gene encoded	Reference
Lung diseases, nephrotic syndrome, epidermolysis syndrome	ITGA3	member of the integrin a chain family of proteins	[86, 87, 88]
Autism	HRH1	histamine receptor H1	[88, 89, 90]
Neurodevelopment disorders, development of learning and memory	eIF4A3 (eukaryote initiation factor 4A3)	eIF4A3	[88, 91, 92]
MPS types/subtypes	ID2	transcription factor DNA binding 2	[88]
Deafness, behavior problem	Homer 2	protein scaffold	[88, 93, 94]
MPS I, MPS IIIA and MPS IIIB	Homer 1	Homer 1 protein	[95]
Cancer diseases	B2M (-2-microglobulin)	-2-microglobulin	[88]
Diabetes	INSR (insulin receptor)	Insulin receptors	[88]
Charcot-Marie Tooth, neurodegenerative diseases	MME (membrane metalloendopeptidase)	Glycoproteins	[96, 97]
Charcot-Marie Tooth, neurodegenerative diseases	CAPN2 (capelin 2, calcium dependent protease)	Calpain-2 catalytic subunit	[96, 97]
Neuropathy and neurodegeneration	APOE	apolipoprotein E	[98]
Neurodegenerative disorders	UCHL1	ubiquitin C-terminal hydrolase L1	[88]
MPS IX, Rigid Spine Muscular Dystrophy 1 and Visceral Heterotaxy	SERPINE2	SERPINE2 protein	[88]
MPS IX, VLDLR-associated cerebellar hypoplasia	VLDLR	lipoprotein receptor	[88]