Table 3.
Animal experiment of treating PCOS with TCM.
| Model | Intervention | Secrete factors | Results | Reference |
|---|---|---|---|---|
| PCOS rats; granulosa cells (GC) | Kidney nourishing and phlegm removing | FBG, TC, TG, LDL, HDL, FFA, APN | The contents of FBG, TC, TG, LDL, and FFA in serum decreased, while the expression of HDL increased. The expression level of APN in serum, AdipoR2 mean density value in ovarian GC membrane, p38MAPK mRNA and FATP1 mean density value in GC cells increased | 2018 (42) |
| PCOS rats | Removing stasis and phlegm method | T, LH, FSH | It can improve PCOS hyperandrogenemia, improve granulosa cell layer number and luteal tissue number, regulate LH/FSH ratio and glucose metabolism | 2015 (44) |
| PCOS rats | Bushen Jieyu Tiaochong Formula | FT, LH, FSH | The abnormal follicular cystic dilation was improved, and the serum FT and LH levels and LH/FSH ratio were decreased | 2021 (46) |
| Obese PCOS rats | Cangfu Daotan Decoction | TC, TG, LDL-C, LH, T, IL-1β, IL-6, TNF-α, HDL, FSH, E2 | Serum TC, TG, LDL-C, LH, T, IL-1β, IL-6, and TNF-α levels were decreased, and HDL, FSH, and E2 levels were increased in a dose-dependent manner | 2021 (76) |
| PCOS rats | Bushen Zhuyun Decoction | / | The expression of PI3K/AKT/mTOR pathway proteins in PCOS rats was upregulated, and the expression of apoptosis-related proteins was downregulated to repair ovarian lesions and improve cell apoptosis | 2021 (77) |
| PCOS rats | Cangfudaotan Decoction | FPG, FNS, FSH, LH, P, T, TNF-α, IL-1β, IL-6, CRP | The levels of FPG, FNS, and HOMA-IR decreased, LH and T decreased, and TNF-α, IL-1β, IL-6, and CRP were inhibited | 2020 (78) |
| PCOS rats | Xiao Yao San | E2, P, LH, NE | The levels of E2 and P in serum decreased, while the levels of LH increased. The formation of vesicles decreased, and apoptosis and autophagy of granulosa cells decreased. The levels of dopamine β-hydroxylase and c-Fos in locus coeruleus increased, and the levels of NE in serum and ovarian tissue decreased | 2017 (79) |
| PCOS rats | Dodder Total Flavone | T, GnRH, LH, E2, FSH | Serum T, GnRH, LH levels, ovarian index, and LH/FSH ratio were significantly decreased, while E2 and FSH levels were significantly increased. It can reduce the expression of AR in the hypothalamus, pituitary gland, and ovary | 2019 (85) |
| PCOS-IR rats | Quercetin | INS, IL-1β, IL-6, TNF-α | The levels of INS, IL-1β, IL-6, and TNF-α in blood were decreased significantly, and IR was decreased | 2017 (90) |
| PCOS rats | Shouwu Jiangqi Decoction | FSH, LH, T | Improves insulin resistance and ovulation disorders | 2016 (91) |
| PCOS-IR rats | Liuwei Dihuang Pills | FSH, E2, P, LH, T | Serum FSH, E2, and P levels increased significantly, while LH and T levels decreased. Ovarian polycystic changes were reduced, and follicular atresia was reduced | 2020 (69) |
PCOS, polycystic ovary syndrome; TCM, traditional Chinese medicine; CRP, C-reactive protein; FBG, fasting blood glucose; FFA, free fatty acid; FPG, fasting plasma glucose; FSH, follicle-stimulating hormone; FT, free testosterone; HDL, high-density lipoprotein; LDL, low-density lipoprotein; NE, norepinephrine; TC, total cholesterol; TG, triglyceride.