Table 4.

Types, components, and characteristics of cholera vaccines.

Cholera vaccines	Components of cholera vaccines	Characteristics of cholera vaccines
Type I (Dukoral ®)	Killed whole-cell and recombinant cholera toxin B vaccine	First internationally licensed oral cholera vaccine
Type II (ORC-Vax™/mORC-Vax™, Shanchol™, Euvichol®, OraVacs)	Killed whole-cell only vaccines	Manufactured without the cholera toxin B to reduce cost and complexity of vaccine administration
Type III (CVD 103, Peru-15, Cuban 638, VA 1.4)	Live attenuated oral cholera vaccine	Mimics the natural cholera infection by inducing mucosal gut immune response
Type IV	Parenteral, killed whole-cell cholera vaccines	Administered for a short period of time due to their side effects in the recipients, limited protection for a short duration, and their inability to limit transmission of cholera