Table 1:
Covariate levels a by quartile of total folate consumption, including folate/folic acid from diet and supplements b
| Total folate intake (DFE/day) b | |||||
|---|---|---|---|---|---|
| All cases N = 248 |
Q1 (125.7–429.9) N = 62 |
Q2 (436.6–793.3) N = 62 |
Q3 (797.1–1256.2) N = 62 |
Q4 (1258.3–3146.0) N = 62 |
|
| Enrollment age (years) | 57±9 | 56±9 | 57±9 | 57±10 | 58±9 |
| Tumor stage | |||||
| 0-I | 49 (20%) | 6 (10%) | 12 (19%) | 16 (26%) | 15 (24%) |
| II | 42 (17%) | 13 (21%) | 10 (16%) | 14 (23%) | 5 (8%) |
| III | 60 (24%) | 17 (27%) | 15 (24%) | 10 (16%) | 18 (29%) |
| IV | 61 (25%) | 15 (24%) | 13 (21%) | 13 (21%) | 20 (32%) |
| Missing | 36 (15%) | 11 (18%) | 12 (19%) | 9 (15%) | 4 (6%) |
| Sex | |||||
| Female | 139 (56%) | 37 (60%) | 34 (55%) | 37 (60%) | 31 (50%) |
| Male | 109 (44%) | 25 (40%) | 28 (45%) | 25 (40%) | 31 (50%) |
| Race | |||||
| White | 77 (31%) | 15 (24%) | 20 (32%) | 19 (31%) | 23 (37%) |
| African American | 168 (68%) | 46 (74%) | 42 (68%) | 41 (66%) | 39 (63%) |
| Hispanic/Latino | 1 (0%) | 0 (0%) | 0 (0%) | 1 (2%) | 0 (0%) |
| Asian or Pacific Islander | 1 (0%) | 0 (0%) | 0 (0%) | 1 (2%) | 0 (0%) |
| 2+ race | 1 (0%) | 1 (2%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Education | |||||
| < 12 years | 72 (29%) | 20 (32%) | 19 (31%) | 18 (29%) | 15 (24%) |
| Completed HS or GED | 76 (31%) | 16 (26%) | 22 (36%) | 23 (37%) | 15 (24%) |
| Some college | 69 (28%) | 21 (34%) | 14 (23%) | 17 (27%) | 17 (27%) |
| College graduate | 30 (12%) | 5 (8%) | 6 (10%) | 4 (6%) | 15 (24%) |
| Household income ($/year) | |||||
| < $15,000 | 133 (55%) | 32 (52%) | 32 (52%) | 38 (63%) | 31 (53%) |
| $15,000–24,999 | 49 (20%) | 13 (21%) | 12 (20%) | 13 (22%) | 11 (19%) |
| $25,000–49,999 | 38 (16%) | 10 (16%) | 11 (18%) | 7 (12%) | 10 (17%) |
| ≥ $50,000 | 21 (9%) | 6 (10%) | 6 (10%) | 2 (3%) | 7 (12%) |
| CRC screening (% yes) | 66 (27%) | 11 (18%) | 22 (35%) | 17 (27%) | 16 (26%) |
| CRC family history (% yes) | 23 (9%) | 7 (11%) | 5 (8%) | 5 (8%) | 6 (10%) |
| Aspirin in the last year (% yes) | 78 (31%) | 18 (29%) | 23 (37%) | 19 (31%) | 18 (29%) |
| Body mass index (kg/m2) | 30±7 | 30±6 | 31±8 | 30±6 | 31±7 |
| Diabetes (% yes) | 78 (31%) | 16 (26%) | 27 (44%) | 13 (21%) | 22 (35%) |
| Smoking status | |||||
| Current | 88 (35%) | 24 (39%) | 19 (31%) | 24 (39%) | 21 (34%) |
| Past | 71 (29%) | 20 (32%) | 13 (21%) | 22 (35%) | 16 (26%) |
| Never | 89 (36%) | 18 (29%) | 30 (48%) | 16 (26%) | 25 (40%) |
| Alcohol b,c | |||||
| Non-drinker | 134 (54%) | 37 (60%) | 36 (58%) | 30 (48%) | 31 (50%) |
| Light/moderate | 79 (32%) | 17 (27%) | 18 (29%) | 21 (34%) | 23 (37%) |
| Heavy | 35 (14%) | 8 (13%) | 8 (13%) | 11 (18%) | 8 (13%) |
| Physical activity (MET/wk) | 22±18 | 17±13 | 23±20 | 21±17 | 26±19 |
| Sedentary activity (Hours/day) | 9±5 | 9±5 | 9±5 | 9±5 | 9±5 |
| Energy intake (kcal/day) | 2476±1403 | 1419±394 | 2140±675 | 2748±1246 | 3597±1790 |
| Meat (servings/day) | 2±1 | 2±1 | 2±1 | 2±1 | 2±1 |
| Fruits/vegetables (servings/day) | 3±2 | 3±1 | 3±1 | 3±2 | 4±2 |
| Fiber (g/day) | 23±14 | 12±4 | 19±6 | 23±11 | 36±18 |
| Healthy Eating Index score d | 60±13 | 58±13 | 60±13 | 58±14 | 65±11 |
Abbreviations: CRC – colorectal cancer, MET – metabolic equivalent, DFE – dietary folate equivalents
Data presented as mean±SD for continuous variables, or as N (%) for categorical variables
Consumption of alcohol and folate from diet and supplements was assessed for the year prior to enrollment.
Non-drinker: 0 drinks per day; Light-drinker: alcohol consumption > 0 and < 1 drink/day for women, < 2 drink/day for men; Heavy drinker: ≥ 1 drink/day for women, ≥ 2 drink/day for men
Calculation of the Healthy Eating Index score, reflecting adherence to the Dietary Guidelines for Americans, has been described previously in the Southern Community Cohort Study (see reference 34).