Table 1.

Medical Marijuana and Me (M³) measures by study design and timepoint of data collection

Study measure	Study type and collection timepoint
	cohort study			cross-sectional study
	baseline	3 months	9 months
Demographics
Age in years	×			×
Race/ethnicity	×			×
Sex at birth	×			×
Gender identity	×			×
Highest level of education	×			×
Employment status	×			×
Veteran status	×			×
Health insurance	×			×
Annual family income in the last year	×			×
ZIP code	×			×
General health
Overall health status (Short Form [SF-8] Health Survey) [12, 13]	×	×	×	×
Depression (PHQ-8) [14, 15]	×	×	×	×
Anxiety (GAD-7) [16]	×	×	×	×
PTSD (adapted from DSM-5 [PC-PTSD-5]) [17, 18]	×	×	×	×
Pain (BPI) [19]	×	×	×	×
Quality of sleep (single item adapted from PSQI) [20]	×	×	×	×
Positive affect (PROMIS) [21, 22]	×	×	×
Anger (PROMIS) [21, 22]	×	×	×
History of cannabis use (including cannabis obtained without a medical card in Florida)
Ever used during a lifetime	×
Age when used for the first time	×			×
Weekly use	×			×
Number of years used weekly	×			×
Daily use	×			×
Number of years used daily	×			×
Cannabis use experience level	×
Cannabis products ever tried before medical cannabis	×
Cannabis use in the last 6 months	×
Frequency of cannabis use in past 6 months (from CUDIT-R) [23]	×		×	×
Frequency of cannabis use in past 3 months (from CUDIT-R) [23]		×
Frequency of cannabis use per day in an average use day	×
Flower use in the past 30 days	×
Frequency of flower use in the past 30 days	×
Frequency of flower use per day in an average use day	×
Ever used CBD	×
Frequency of CBD use in past 6 months	×
Amount of money spent on cannabis in a typical month	×
Alcohol and other substance use
Alcohol use (AUDIT-C) [24]	×	×	×	×
Cigarette smoking use (from BRFSS) [25]	×	×	×
E-cigarette/vape use (from BRFSS) [25]	×	×	×
Frequency of opioid use (with prescription) in past 30 days	×	×	×
Frequency of opioid use (without prescription) in past 30 days	×	×	×
Frequency of benzodiazepine use (with prescription) in past 30 days	×	×	×
Frequency of benzodiazepine use (without prescription) in past 30 days	×	×	×
Frequency of amphetamine use (with prescription) in past 30 days	×	×	×
Frequency of amphetamine use (with prescription) in past 30 days	×	×	×
Frequency of cocaine/crack use in past 30 days	×	×	×
Frequency of hallucinogens use in past 30 days	×	×	×
Frequency of synthetic cannabis use in past 30 days	×	×	×
Frequency of kratom use in past 30 days	×	×	×
Use of recreational substance to track	×
Substance name to track (up to 3 substances)	×
Change in substance tracked		×	×
Use of (alcohol, cigarettes, vapes, cocaine, hallucinogens, club drugs, synthetic cannabis, and kratom) in past 5 years				×
Change in (alcohol, cigarettes, vapes, cocaine, hallucinogens, club drugs, synthetic cannabis, kratom) since starting medical cannabis				×
Is change in use (alcohol, cigarettes, vapes, cocaine, hallucinogens, club drugs, synthetic cannabis, kratom) related to medical cannabis?				×
Use of (opioids with and without prescription, amphetamines with and without prescription, benzodiazepines with and without prescription) in the past 5 years				×
Change in (opioids with and without prescription, amphetamines with and without prescription, benzodiazepines with and without prescription) since starting medical cannabis				×
Is change in use (opioids with and without prescription, amphetamines with and without prescription, benzodiazepines with and without prescription) related to medical cannabis?				×
Medications
List of current medications (medication name, dose, frequency of use, and route of administration)	×	×	×	×
Use of medications to track	×
Medications names to track (up to 3)	×
Change in medications tracked		×	×
Tried to reduce specific medications in past 5 years				×
Name of 3 medications tried to reduce in past 5 years				×
Overall change of medication use since starting medical cannabis				×
Is a change in medication use related to medical cannabis?				×
Medical conditions
Medical conditions diagnosed by healthcare professional	×			×
Cancer: type of cancer	×			×
Cancer: metastasis	×	×	×	×
Cancer: current cancer status	×	×	×	×
Cancer: current cancer treatment	×	×	×	×
Medical cannabis effect on medical conditions		×	×	×
Method of cannabis use that was most effective for each condition		×	×	×
Name of product that works best for each condition		×	×	×
Other health benefits of medical cannabis		×	×	×
Knowledge of care providers about medical cannabis use		×	×	×
Cancer: knowledge of oncologist/provider about use/intent to use	×	×	×	×
Reasons for using or stopping medical cannabis
Medical conditions that are reasons for medical cannabis use	×			×
Certified medical condition	×			×
Cancer: cancer-specific reason for use	×			×
Cannabis use motive (recreational vs. medical)	×	×	×	×
Reasons for stopping		×	×
Thinking about stopping use		×	×
Reasons for thinking about stopping use		×	×
Expectations
Expected effectiveness
Concern about addiction/dependence on medical cannabis	×	×	×	×
Likelihood to be taking cannabis in a year	×	×	×	×
Duration of medical cannabis use
Still using medical cannabis		×	×
Duration of medical cannabis use		×	×	×
Duration of use before stopping		×	×
Year first obtained medical cannabis card in Florida				×
Medical cannabis products
Products tried from the medical cannabis program in Florida (flower, vaporizer cartridges or vape pen (liquid, not flower), concentrates (for vaping or smoking), topicals, oral tinctures (with a dropper), oral concentrates, oral capsules or edibles (chews, lozenges, chocolates, or gels), other		×	×	×
Products used in the past 30 days (all products)		×	×	×
Reasons for not using the product (all products)		×	×	×
Frequency of product use in past 30 days		×	×	×
Frequency of product use in a typical day (all products)		×	×	×
THC concentration (all products)		×	×	×
Duration to effect onset (all products)		×	×	×
Duration of effects to last (all products)		×	×	×
CBD: THC ratio (all products)		×	×	×
Number of strains tried (all products)		×	×	×
Strain used most (all products)		×	×	×
Duration to consume one flower container		×	×	×
Number of flower containers used per month		×	×	×
Frequency of methods to consume flower in past 30 days (smoking, vaping, cooking)		×	×	×
Number of hits, tokes, or puffs per session when smoking/vaping flower/cartridges/concentrates		×	×	×
Number of seconds when inhaling smoke or vape		×	×	×
Frequency of using concentrate methods in past 30 days (shatter, rosin, wax, keif, crumble, dab tab, hash)		×	×	×
Frequency of using at least 25 mg (rice-sized) of concentrate in past 30 days		×	×	×
Frequency of using topical methods in past 30 days (patch, cream, lotion, balms, salves, spray, transdermal gel, oil)		×	×	×
Milliliters of tincture consumed per occasion		×	×	×
Average milligrams of THC and CBD consumed when using tinctures
Frequency of using oral concentrate methods in past 30 days (distillate syringe, RSO syringe)		×	×	×
Amount of oral concentrate per occasion		×	×	×
Frequency of oral methods in past 30 days (capsule/tablets, gel/gummies, brownie/cookie)		×	×	×
Amount spent on products per month in USD		×	×	×
Overall preferred medical cannabis and/or a product type or strain		×	×	×
Preferred method of using medical cannabis		×	×	×
Name of overall preferred strain/product		×	×	×
Amount of used cannabis from a Florida dispensary		×	×
Side effects
Symptoms bothered by in the past 2 weeks	×	×	×	×
Were symptoms caused by medical cannabis?		×	×	×
Severe side effects requiring an emergency room visit, seeing a physician, being hospitalized, or feeling extremely sick for a few hours		×	×	×
Describe severe side effects		×	×	×
Frequency of severe side effects		×	×	×
Concurrent use of substance/medication when severe side effect occurred		×	×	×
Mode of consumption when severe side effect occurred		×	×	×
Cannabis use disorder (CUDIT-R) [23]	×	×	×	×
Beliefs and opinions
Agree that cannabis products with high THC will be more effective	×	×	×	×
Preference to try low-THC products	×	×	×	×
Importance of CBD in the medical effects of medical cannabis	×	×	×	×
Importance of including terpenes in medical cannabis products	×	×	×	×
Factors influencing products tried		×	×	×
Interest in growing own medical cannabis if it becomes legal in Florida		×	×	×
Additional topics that should be researched	×			×

AUDIT-C, Alcohol Use Disorders Identification Test-Concise [24]; BPI, Brief Pain Inventory [19]; BRFSS, Behavioral Risk Factor Surveillance System [25]; CBD, cannabidiol; CUDIT-R, Cannabis Use Disorders Identification Test-Revised [23]; DSM-5 (PC-PTSD-5), Primary Care Posttraumatic Stress Disorder Screen for the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition [17, 18]; GAD-7, General Anxiety Disorder-7 [16]; PHQ-8, eight-item Patient Health Questionnaire depression scale [14, 15]; PTSD, posttraumatic stress disorder [17, 18]; PROMIS, Patient-Reported Outcomes Measurement Information System [21, 22]; PSQI, Pittsburgh Sleep Quality Index [20]; SF-8, Short Form 8 [12, 13]; THC, tetrahydrocannabinol.