Table 2.

Mixed model results.

Model	Effect	DF	F	p
MADRS total	Age	1/567	17.1	<0.0001
	Time		388.8	<0.0001
	Age × Time		3.5	n.s.
MADRS items	Age	1/567	17.1	<0.0001
	Time	1/10773	510.1	<0.0001
	Item		639.5	<0.0001
	Age × Time		4.6	0.033*
	Age × Item		9.5	<0.0001
	Item × Time		1.3	n.s.
	Age × Time × Item		0.5	n.s.
Post hoc models (stratified by item)
Inner tension	Age	1/567	10.8	0.001
	Time		124.3	<0.0001
	Age × Time		2.9	n.s.
Reduced appetite	Age	1/567	33.5	<0.0001
	Time		97.4	<0.0001
	Age × Time		4.1	0.045*
Concentration difficulties	Age	1/567	13.9	0.0002
	Time		87.5	<0.0001
	Age × Time		0.33	n.s.
Lassitude	Age	1/567	10.1	0.001
	Time		100.4	<0.0001
	Age × Time		2.6	n.s.
Inability to feel	Age	1/567	4.7	0.03 *
	Time		131.2	<0.0001
	Age × Time		2.3	n.s.

Note: Associations not withstanding correction for multiple comparison are marked with *.

Abbreviations: DF, degrees of freedom (numerator/denominator); MADRS, Montgomery–Åsberg Depression Rating Scale.