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. 2023 May 27;18(1):2217033. doi: 10.1080/15592294.2023.2217033

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 4. — Lnc KCNQ1OT1 indirectly elevated MDR1 expression to promote DOX resistance of BC cells and DOX-resistant BC cells.Note: DOX-resistant BC cells were transfected with sh-lnc KCNQ1OT1 alone or along with oe-MDR1. a, qRT-PCR was employed to detect lnc KCNQ1OT1, miR-103a-3p, and MDR1 expressions. b, cell viability was determined by MTT. c, cell proliferation was detected using clone formation. d, the apoptosis rate and cell cycle were measured with flow cytometry. e, western blot was performed to measure MDR1, cyclin D1, Bax, and Bcl-2 expressions.