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. 2023 Mar 20;136(9):1098–1110. doi: 10.1097/CM9.0000000000002201

Figure 5.

Figure 5

AC005224.4 impacted the expression of SNAI2. (A, B) The expression profiles of mRNAs in five pairs of ovarian cancer tissues and normal ovarian tissues were analyzed. Differentially expressed lncRNAs were displayed in the volcano plot (A) and heat-map (B) and the threshold value was set to P values <0.05 and fold change-values >1. (C) The co-expression network of AC005224.4 and mRNAs based on our microarray and TCGA-ovarian cancer database was established. (D) The effect of AC005224.4 on SNAI2 expression in SKOV3 and CAOV-3 cells was explored. N = 3; †P < 0.01, compared with the vector group or si-NC group. (E) The expression level of SNAI2 in ovarian cancer and normal tissues was detected. ‡P < 0.001, compared with normal tissues. (F) SNAI2 expression level in different ovarian carcinoma cell lines (SNU119, SKOV3, CAOV-3, and HO8910 cells) and HOSEpiC was detected. N = 3; ∗P < 0.05, †P < 0.01 compared with HOSEpiC cells. HOSEpiC: Human ovarian epithelial cells; LncRNA: Long non-coding RNA.