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. Author manuscript; available in PMC: 2023 May 30.
Published in final edited form as: J Med Chem. 2022 Dec 20;66(1):122–139. doi: 10.1021/acs.jmedchem.2c01599

Chart 5. Chemical Structures and PKD1 Inhibitory Activities (Ki’s) of Conformationally Rigidified Chemotype IV Analogsa.

Chart 5.

aThe ratio of NIK/PKD1 Ki’s is shown in parentheses. The higher the ratio, the greater the selectivity for PKD1.41