Table 5.
TOPCAT primary outcome events, cardiovascular mortality, cause-specific mortality, and other cardiovascular events for full (unmatched) and propensity score–matched cohorts
| Full cohort | PSM cohort | Full cohort | PSM cohort | |||||
|---|---|---|---|---|---|---|---|---|
| Any AF (n = 760) | No AF (n = 1005) | Any AF (n = 584) | No AF (n = 584) | AF on ECG (n = 446) | No AF on ECG (n = 1005) | AF on ECG (n = 418) | No AF on ECG (n = 418) | |
| TOPCAT composite primary endpoint | 241 (31.7%) | 281 (28.0%) | 196 (33.6%) | 147 (25.2%) | 148 (33.2%) | 374 (28.4%) | 141 (33.7%) | 100 (23.9%) |
| Cardiovascular death | 110 (14.5%) | 113 (11.2%) | 92 (15.8%) | 67 (11.5%) | 74 (16.6%) | 149 (11.3%) | 71 (17.0%) | 52 (12.4%) |
| Any sudden cardiac death | 29 (3.8%) | 48 (4.8%) | 27 (4.6%) | 25 (4.3%) | 20 (4.5%) | 57 (4.3%) | 19 (4.5%) | 20 (4.8%) |
| Pump failure death | 37 (4.9%) | 23 (2.3%) | 30 (5.1%) | 15 (2.6%) | 27 (6.1%) | 33 (2.5%) | 25 (6.0%) | 12 (2.9%) |
| Cardiovascular hospitalization | 309 (40.7%) | 380 (37.8%) | 250 (42.8%) | 197 (33.7%) | 178 (39.9%) | 511 (38.7%) | 170 (40.7%) | 136 (32.5%) |
| Worsening HF (HF I/II to III/IV) | 225 (45.6%) | 233 (36.0%) | 178 (45.4%) | 140 (36.3%) | 123 (44.4%) | 335 (38.8%) | 115 (43.9%) | 115 (41.1%) |
| Hospitalization for HF | 185 (24.3%) | 215 (21.4%) | 148 (25.3%) | 103 (17.6%) | 112 (25.1%) | 288 (21.8%) | 106 (25.4%) | 69 (16.5%) |
| Follow-up (years)—median (25th–75th %) | 3.4 (2.09, 4.53) | 3.43 (2.34, 4.53) | 3.47 (2.06, 4.90) | 3.49 (2.44, 4.57) | ||||
AF, atrial fibrillation; HF, heart failure.